Western Blot (WB)
(SCN1B Antibody (N-Term) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the SCN1B antibody detected the SCN1B protein (arrow).)
Rabbit SCN1B Polyclonal Antibody | anti-SCN1B antibody
SCN1B Antibody (N-Term)
Western Blot (WB)
(SCN1B Antibody (N-Term) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the SCN1B antibody detected the SCN1B protein (arrow).)
Western Blot (WB)
(SCN1B Antibody (N-Term) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the SCN1B antibody detected the SCN1B protein (arrow).)
Immunohistochemistry (IHC)
(SCN1B Antibody (N-Term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SCN1B Antibody (N-Term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(SCN1B Antibody (N-Term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SCN1B Antibody (N-Term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Flow Cytometry (FC/FACS)
(SCN1B Antibody (N-Term) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(SCN1B Antibody (N-Term) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
that function in the generation and propagation of action
potentials in muscle and neuronal cells. They are composed of one
alpha and two beta subunits, where the alpha subunit provides
channel activity and the beta-1 subunit modulates the kinetics of
channel inactivation. SCN1B encodes a sodium channel beta-1
subunit. Mutations in this gene result in generalized epilepsy with
febrile seizures plus, Brugada syndrome 5, and defects in cardiac
conduction. Multiple transcript variants encoding different
isoforms have been found for this gene.
Tan, B.H., et al. Heart Rhythm 7(6):771-778(2010)
Casini, S., et al. Cardiovasc. Res. 85(4):691-700(2010)
Ogawa, R., et al. Int J Clin Pharmacol Ther 48(2):109-119(2010)
Watanabe, H., et al. Circ Arrhythm Electrophysiol 2(3):268-275(2009)
NCBI and Uniprot Product Information
NCBI Description
Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Uniprot Description
SCN1B: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. Defects in SCN1B are the cause of generalized epilepsy with febrile seizures plus type 1 (GEFS+1). Generalized epilepsy with febrile seizures-plus refers to a rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity. Defects in SCN1B are the cause of Brugada syndrome type 5 (BRGDA5). A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Channel, sodium
Chromosomal Location of Human Ortholog: 19q13.1
Cellular Component: voltage-gated sodium channel complex; T-tubule; extracellular region
Molecular Function: sodium channel inhibitor activity; sodium channel regulator activity; voltage-gated sodium channel activity
Biological Process: membrane depolarization; synaptic transmission; axon guidance; action potential propagation; corticospinal neuron axon guidance; cell adhesion; locomotion; response to pyrethroid; cardiac muscle contraction
Disease: Generalized Epilepsy With Febrile Seizures Plus, Type 1; Atrial Fibrillation, Familial, 13; Brugada Syndrome 5
Research Articles on SCN1B
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Product Notes
The SCN1B scn1b (Catalog #AAA9203110) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 63-90. The SCN1B Antibody (N-Term) reacts with Human, mouse (Predicted Reactivity: Bovine, Rabbit, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's SCN1B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS). WB~~1:1000. Researchers should empirically determine the suitability of the SCN1B scn1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SCN1B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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