PACS2 blocking peptide

PACS2 Antibody (C-term) Blocking Peptide

• Gene Names: PACS2; PACS-2; PACS1L
• Synonyms: PACS2; PACS2 Antibody (C-term) Blocking Peptide; Phosphofurin acidic cluster sorting protein 2; PACS-2; PACS1-like protein; KIAA0602; PACS1L; PACS2 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of PACS2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 889

• Cellular Location: Endoplasmic reticulum lumen. Mitochondrion
• Tissue Location: Broadly expressed, with greatest levels in skeletal muscle followed by heart, brain, pancreas and testis
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PACS2 blocking peptide

Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.

NCBI and Uniprot Product Information

• NCBI GI #: 117949768
• NCBI GeneID: 23241
• UniProt Accession #: Q86VP3; O60342; Q6P191; Q96FL7; A2VDJ9; G8JLK3
• Molecular Weight: 89,609 Da
• NCBI Official Full Name: Phosphofurin acidic cluster sorting protein 2
• NCBI Official Synonym Full Names: phosphofurin acidic cluster sorting protein 2
• NCBI Official Symbol: PACS2
• NCBI Official Synonym Symbols: PACS-2; PACS1L
• NCBI Protein Information: phosphofurin acidic cluster sorting protein 2
• UniProt Protein Name: Phosphofurin acidic cluster sorting protein 2
• Protein Family: Phosphofurin acidic cluster sorting protein
• UniProt Gene Name: PACS2
• UniProt Synonym Gene Names: KIAA0602; PACS1L; PACS-2
• UniProt Entry Name: PACS2_HUMAN

Uniprot Description

PACS2: Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. Belongs to the PACS family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: endoplasmic reticulum

Biological Process: autophagic vacuole formation