NME4 blocking peptide

NME4 Antibody (N-term) Blocking Peptide

• Gene Names: NME4; NDPK-D; NM23H4; nm23-H4
• Synonyms: NME4; NME4 Antibody (N-term) Blocking Peptide; Nucleoside diphosphate kinase; mitochondrial; NDK; NDP kinase; Nucleoside diphosphate kinase D; NDPKD; nm23-H4; NM23D; NME4 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human NME4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 187

• Cellular Location: Mitochondrion intermembrane space.
• Tissue Location: Widely distributed. Found at very high levels in prostate, heart, liver, small intestine, and skeletal muscle tissues, and in low amounts in the brain and in blood leukocytes
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for NME4 blocking peptide

Major role in the synthesis of nucleoside triphosphates other than ATP.

NCBI and Uniprot Product Information

• NCBI GI #: 2498075
• NCBI GeneID: 4833
• UniProt Accession #: O00746; Q5U0M9; A2IDD0
• Molecular Weight: 12,979 Da
• NCBI Official Full Name: Nucleoside diphosphate kinase, mitochondrial
• NCBI Official Synonym Full Names: NME/NM23 nucleoside diphosphate kinase 4
• NCBI Official Symbol: NME4
• NCBI Official Synonym Symbols: NDPK-D; NM23H4; nm23-H4
• NCBI Protein Information: nucleoside diphosphate kinase, mitochondrial
• UniProt Protein Name: Nucleoside diphosphate kinase, mitochondrial
• UniProt Gene Name: NME4
• UniProt Synonym Gene Names: NM23D; NDK; NDP kinase, mitochondrial; NDPKD
• UniProt Entry Name: NDKM_HUMAN

NCBI Description

The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 [PubMed 9099850]).[supplied by OMIM, May 2008]

Uniprot Description

NME4: Major role in the synthesis of nucleoside triphosphates other than ATP. Belongs to the NDK family.

Protein type: Kinase, nucleoside diphosphate; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; EC 2.7.4.6; Kinase, other; Mitochondrial; Other group; NDK family

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: mitochondrial inner membrane; mitochondrion

Molecular Function: nucleoside diphosphate kinase activity; protein binding

Biological Process: nucleobase, nucleoside and nucleotide interconversion; nucleoside metabolic process; nucleoside triphosphate biosynthetic process; purine nucleotide metabolic process; pyrimidine nucleotide metabolic process; regulation of apoptosis