LILRA3 blocking peptide

LILRA3 Blocking Peptide (C-term)

Gene Names

LILRA3; HM31; HM43; ILT6; LIR4; CD85E; ILT-6; LIR-4

Synonyms

LILRA3; LILRA3 Blocking Peptide (C-term); Leukocyte immunoglobulin-like receptor subfamily A member 3; CD85 antigen-like family member E; Immunoglobulin-like transcript 6; ILT-6; Leukocyte immunoglobulin-like receptor 4; LIR-4; Monocyte inhibitory receptor HM43/HM31; CD85e; ILT6; LIR4; LILRA3 blocking peptide

Ordering

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

439

Cellular Location

Secreted.

Tissue Location

Detected in B-cells, and at lower levels in natural killer (NK) cells. Detected in peripheral blood monocytes and lung.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for LILRA3 blocking peptide

Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS- induced TNF-alpha production by monocytes.

NCBI and Uniprot Product Information

NCBI GI #

92090611

NCBI GeneID

11026

UniProt Accession #

Q8N6C8; O15469; O15470; O75016; Q8N151; Q8N154; Q8NHJ1; Q8NHJ2; Q8NHJ3; Q8NHJ4; J3KPM2

Molecular Weight

49,187 Da

NCBI Official Full Name

Leukocyte immunoglobulin-like receptor subfamily A member 3

NCBI Official Synonym Full Names

leukocyte immunoglobulin like receptor A3

NCBI Official Symbol

LILRA3

NCBI Official Synonym Symbols

HM31; HM43; ILT6; LIR4; CD85E; ILT-6; LIR-4

NCBI Protein Information

leukocyte immunoglobulin-like receptor subfamily A member 3

UniProt Protein Name

Leukocyte immunoglobulin-like receptor subfamily A member 3

Protein Family

Leukocyte immunoglobulin-like receptor subfamily

UniProt Gene Name

LILRA3

UniProt Synonym Gene Names

ILT6; LIR4; ILT-6; LIR-4

UniProt Entry Name

LIRA3_HUMAN

NCBI Description

This gene encodes a member of a family of immunoreceptors that are expressed predominantly in monocytes and B cells, and at lower levels in dendritic cells and natural killer cells. The encoded protein lacks the transmembrane region found in other members of this family. It acts as a soluble receptor for class I major histocompatibility complex (MHC) antigens. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and is polymorphic in human populations, with many individuals containing a deletion of this genomic region. [provided by RefSeq, Mar 2014]

Uniprot Description

LILRA3: May act as soluble receptor for class I MHC antigens.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: plasma membrane

Molecular Function: antigen binding; receptor activity

Biological Process: defense response; signal transduction

Research Articles on LILRA3

1. Evidence showed lack of significant association between LILRA3 deletion and multiple sclerosis pathogenesis. [meta-analysis]

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Product Notes

The LILRA3 lilra3 (Catalog #AAA9229083) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LILRA3, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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LILRA3 blocking peptide