FUS blocking peptide

FUS Antibody (C-term) Blocking peptide

• Gene Names: FUS; TLS; ALS6; ETM4; FUS1; POMP75; HNRNPP2
• Synonyms: FUS; FUS Antibody (C-term) Blocking peptide; RNA-binding protein FUS; 75 kDa DNA-pairing protein; Oncogene FUS; Oncogene TLS; POMp75; Translocated in liposarcoma protein; TLS; FUS blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 525

• Cellular Location: Nucleus
• Tissue Location: Ubiquitous
• Function: FunctionDNA/RNA-binding protein that plays a role invarious cellular processes such astranscription regulation, RNA splicing, RNAtransport, DNA repair and damage response(PubMed:27731383). Binds tonascent pre-mRNAs and acts as a molecularmediator between RNA polymerase II and U1small nuclear ribonucleoprotein therebycoupling transcription and splicing(PubMed:26124092). Binds alsoits own pre- mRNA and autoregulates itsexpression; this autoregulation mechanism ismediated by non-sense-mediated decay(PubMed:24204307). Plays arole in DNA repair mechanisms by promotingD-loop formation and homologousrecombination during DNA double-strandbreak repair (PubMed:10567410). Inneuronal cells, plays crucial roles in dendriticspine formation and stability, RNA transport,mRNA stability and synaptic homeostasis (By similarity).
• Preparation and Storage: Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.

Related Product Information for FUS blocking peptide

Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.

Background: This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type6.

NCBI and Uniprot Product Information

• NCBI GI #: 283135201
• NCBI GeneID: 2521
• NCBI Accession #: NP_001164105.1
• NCBI GenBank Nucleotide #: NM_001170634.1
• UniProt Accession #: P35637; Q9H4A8
• NCBI Official Full Name: RNA-binding protein FUS isoform 2
• NCBI Official Synonym Full Names: FUS RNA binding protein
• NCBI Official Symbol: FUS
• NCBI Official Synonym Symbols: TLS; ALS6; ETM4; FUS1; POMP75; HNRNPP2
• NCBI Protein Information: RNA-binding protein FUS
• UniProt Protein Name: RNA-binding protein FUS
• Protein Family: Fusion protein
• UniProt Gene Name: FUS
• UniProt Synonym Gene Names: TLS
• UniProt Entry Name: FUS_HUMAN

NCBI Description

This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]

Uniprot Description

hnRNP P2: Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity. Component of nuclear riboprotein complexes. Interacts with ILF3, TDRD3 and SF1. Interacts through its C-terminus with SFRS13A. Interacts with OTUB1 and SARNP. Ubiquitous. Belongs to the RRM TET family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; RNA-binding; Oncoprotein; DNA-binding; RNA splicing

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: nucleoplasm; nucleus

Molecular Function: identical protein binding; protein binding; RNA binding; transcription coactivator activity

Biological Process: nuclear mRNA splicing, via spliceosome

Disease: Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia; Tremor, Hereditary Essential, 4