FIGLA blocking peptide

FIGLA Antibody (Center) Blocking Peptide

• Gene Names: FIGLA; POF6; BHLHC8; FIGALPHA
• Synonyms: FIGLA; FIGLA Antibody (Center) Blocking Peptide; Factor in the germline alpha; FIGalpha; Class C basic helix-loop-helix protein 8; bHLHc8; Folliculogenesis-specific basic helix-loop-helix protein; Transcription factor FIGa; BHLHC8; FIGLA blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 219

• Cellular Location: Nucleus.
• Tissue Location: Germ cells. Expressed in the fetal ovary, but not by a range of other tissues. Expression increases across mid- gestation, rising some 40-fold by the time of primordial follicle formation.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for FIGLA blocking peptide

Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E- box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters.

NCBI and Uniprot Product Information

• NCBI GI #: 296434505
• NCBI GeneID: 344018
• UniProt Accession #: Q6QHK4
• Molecular Weight: 24,123 Da
• NCBI Official Full Name: Factor in the germline alpha
• NCBI Official Synonym Full Names: folliculogenesis specific bHLH transcription factor
• NCBI Official Symbol: FIGLA
• NCBI Official Synonym Symbols: POF6; BHLHC8; FIGALPHA
• NCBI Protein Information: factor in the germline alpha
• UniProt Protein Name: Factor in the germline alpha
• Protein Family: Factor in the germline
• UniProt Gene Name: FIGLA
• UniProt Synonym Gene Names: BHLHC8; FIGalpha; bHLHc8
• UniProt Entry Name: FIGLA_HUMAN

NCBI Description

This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type 6. [provided by RefSeq, Sep 2009]

Uniprot Description

FIGLA: Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E- box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters. Defects in FIGLA are the cause of premature ovarian failure type 6 (POF6). An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.

Chromosomal Location of Human Ortholog: 2p13.3

Cellular Component: transcription factor complex

Molecular Function: sequence-specific DNA binding; transcription factor binding

Disease: Premature Ovarian Failure 6