EIF2S3L blocking peptide

EIF2S3L Antibody (Center) Blocking Peptide

• Synonyms: EIF2S3L; EIF2S3L Antibody (Center) Blocking Peptide; Putative eukaryotic translation initiation factor 2 subunit 3-like protein; Eukaryotic translation initiation factor 2 subunit gamma A; eIF-2-gamma A; eIF-2gA; EIF2S3L blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 472

• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for EIF2S3L blocking peptide

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 205830883
• UniProt Accession #: Q2VIR3; Q5I0X0; Q6KF84
• Molecular Weight: 50,544 Da
• NCBI Official Full Name: Putative eukaryotic translation initiation factor 2 subunit 3-like protein
• UniProt Protein Name: Putative eukaryotic translation initiation factor 2 subunit 3-like protein
• Protein Family: Putative eukaryotic translation initiation factor 2 subunit 3-like protein
• UniProt Gene Name: EIF2S3L
• UniProt Synonym Gene Names: eIF-2gA
• UniProt Entry Name: IF2GL_HUMAN

Uniprot Description

As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage ().