CDCA8 blocking peptide

CDCA8 Antibody (N-term) Blocking peptide

• Gene Names: CDCA8; BOR; DasraB; MESRGP; BOREALIN
• Synonyms: CDCA8; CDCA8 Antibody (N-term) Blocking peptide; Borealin; Cell division cycle-associated protein 8; Dasra-B; hDasra-B; Pluripotent embryonic stem cell-related gene 3 protein; PESCRG3; CDCA8 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 280

• Cellular Location: Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere. Note: Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with SENP3 in the nucleolus in interphase cells
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CDCA8 blocking peptide

Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.

NCBI and Uniprot Product Information

• NCBI GI #: 110832774
• NCBI GeneID: 55143
• UniProt Accession #: Q53HL2; Q53HN1; Q96AM3; Q9NVW5; D3DPT4
• Molecular Weight: 31,323 Da
• NCBI Official Full Name: Borealin
• NCBI Official Synonym Full Names: cell division cycle associated 8
• NCBI Official Symbol: CDCA8
• NCBI Official Synonym Symbols: BOR; DasraB; MESRGP; BOREALIN
• NCBI Protein Information: borealin
• UniProt Protein Name: Borealin
• UniProt Gene Name: CDCA8
• UniProt Synonym Gene Names: PESCRG3; hDasra-B
• UniProt Entry Name: BOREA_HUMAN

NCBI Description

This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]

Uniprot Description

Borealin: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. Belongs to the borealin family.

Protein type: Nucleolus; Cell cycle regulation

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: chromosome, pericentric region; cytosol; intercellular bridge; midbody; nucleolus; nucleoplasm; nucleus; protein complex; spindle midzone

Molecular Function: protein binding

Biological Process: chromosome organization and biogenesis; mitotic metaphase plate congression; protein sumoylation; sister chromatid cohesion