Chemical Structure
(Chemical structure of YM-08 (SIH-122), a Hsp70 Inhibitor. CAS #: N/A. Molecular Formula: C19H17N3OS2. Molecular Weight: 367.49 g/mol.)
YM-08 small molecule
YM-08
Purity
>99% (HPLC)
Synonyms
YM-08; Hsp70 Inhibitor; (2Z; 5E)-3-ethyl-5-(3-methyl-1; 3-benzothiazol-2-ylidene)-2-(pyridin-2-ylmethylidene)-1; 3-thiazolidin-4-one; YM8; YM08; YM-08 small molecule
Host
Synthetic
Purity/Purification
>99% (HPLC)
Form/Format
Yellow-orange solid
Solubility
Soluble in DMSO
Molecular Formula
C19H17N3OS2
SMILES
O=C2C(\S\C(=C\c1ncccc1)N2CC)=C3\Sc4ccccc4N3C
Preparation and Storage
Store at -20 degree C.
Chemical Structure
(Chemical structure of YM-08 (SIH-122), a Hsp70 Inhibitor. CAS #: N/A. Molecular Formula: C19H17N3OS2. Molecular Weight: 367.49 g/mol.)
Chemical Structure
(Chemical structure of YM-08 (SIH-122), a Hsp70 Inhibitor. CAS #: N/A. Molecular Formula: C19H17N3OS2. Molecular Weight: 367.49 g/mol.)
Related Product Information for YM-08 small molecule
YM-08 is a Heat Shock Protein 70 (Hsp70) inhibitor that is blood-brain barrier permeable. YM-08 is a neutral derivative of the Hsp70 inhibitor MKT-077. MKT-077 reduces tau levels in cellular models, but it doesn?t penetrate the blood brain barrier. Although YM-08 was somewhat less effective than MKT-077 in anti-tau and anticancer assays, it selectively reduced pathogenic tau in brain slices, which MKT-077 did not. Furthermore,YM-08 was not retained in the kidney leading one to speculate that it would not have the nephrotoxicity that was a problem for MKT-077 in clinical trials.
Product Categories/Family for YM-08 small molecule
References
1. Miyata, Y. et al. 2013 ACS Chemical Neuroscience Jun 19;4(6):930-9. doi: 10.1021/cn300210g
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Product Notes
The YM-08 (Catalog #AAA807929) is a Small Molecule produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "YM-08, Small Molecule" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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