Brsk2 blocking peptide
Mouse Brsk2 Antibody (Center) Blocking Peptide
Gene Names
Brsk2; SADA; SAD-A; 4833424K13Rik
Synonyms
Brsk2; Mouse Brsk2 Antibody (Center) Blocking Peptide; Serine/threonine-protein kinase BRSK2; Brain-specific serine/threonine-protein kinase 2; BR serine/threonine-protein kinase 2; Serine/threonine-protein kinase SAD-A; Kiaa4256; Sada; Brsk2 blocking peptide
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
735
Cellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note: Detected at centrosomes during mitosis Localizes to the endoplasmic reticulum in response to stress caused by tunicamycin (By similarity).
Tissue Location
Detected in pancreas islets and in brain (at protein level). Detected in brain and pancreas
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for Brsk2 blocking peptide
Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-504' and 'Ser-554'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-175 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-261 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmatic reticulum (ER) stress.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
73,150 Da
NCBI Official Full Name
Serine/threonine-protein kinase BRSK2
NCBI Official Synonym Full Names
BR serine/threonine kinase 2
NCBI Official Symbol
Brsk2
NCBI Official Synonym Symbols
SADA; SAD-A; 4833424K13Rik
NCBI Protein Information
serine/threonine-protein kinase BRSK2
UniProt Protein Name
Serine/threonine-protein kinase BRSK2
Protein Family
UniProt Gene Name
Brsk2
UniProt Synonym Gene Names
Kiaa4256; Sada; BR serine/threonine-protein kinase 2
UniProt Entry Name
BRSK2_MOUSE
Uniprot Description
BRSK2: a serine/threonine protein kinase of the CAMK group. Closely related to AMPK. Activated by the kinase LKB1. BRSK1 and BRSK2 are required for nueronal polarization. Expressed in the brain and at low levels in the testis. Four alternatively spliced isoforms have been described.
Protein type: Protein kinase, CAMK; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.26; CAMK group; CAMKL family; BRSK subfamily
Cellular Component: centrosome; cytoplasm; endoplasmic reticulum; intracellular; nucleus
Molecular Function: ATP binding; ATPase binding; magnesium ion binding; protein binding; protein kinase binding; protein serine/threonine kinase activity; tau-protein kinase activity
Biological Process: actin cytoskeleton reorganization; axonogenesis; establishment of cell polarity; G2/M transition of mitotic cell cycle; neurite morphogenesis; neuron differentiation; peptidyl-serine phosphorylation; protein amino acid phosphorylation
Research Articles on Brsk2
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Product Notes
The Brsk2 brsk2 (Catalog #AAA9221409) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Brsk2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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