BRCAA1 blocking peptide

BRCAA1 (D810) Peptide

Cat. Num. AAA3003208

• Gene Names: ARID4B; BCAA; BRCAA1; RBP1L1; SAP180; RBBP1L1
• Applications: Blocking
• Purity: Synthetic peptide BRCAA1 (D810). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: BRCAA1; BRCAA1 (D810) Peptide; AT-rich interactive domain-containing protein 4B; ARID domain-containing protein 4B; 180 kDa Sin3-associated polypeptide; Sin3-associated polypeptide p180; Breast cancer-associated antigen BRCAA1; Histone deacetylase complex subunit SAP180; Retinoblastoma-binding protein 1-like 1; ARID4B; RBBP1L1; RBP1L1; SAP180; BRCAA1 blocking peptide

• Specificity: This peptide can be used with studies using MBS3003207 BRCAA1 (D810) pAb.
• Purity/Purification: Synthetic peptide BRCAA1 (D810). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 1312

• Applicable Applications for BRCAA1 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for BRCAA1 blocking peptide

The breast cancer-associated antigen BRCAA1, also designated ARID domaincontaining protein 4B (ARID4B), Sin3-associated polypeptide p180 (SAP180), or Retinoblastoma-binding protein 1-like 1 (RBBP1L1 or RBP1L1), shares 37% amino acid identity and an identical antigen epitope, SSKKQKRSHK, with Rb binding protein 1. High expression of BRCAA1 mRNA has been found in human breast, lung, colon, pancreatic and ovarian cancers, as well as in normal testis. This expression pattern indicates that BRCAA1 can be uses as a molecular marker for a broad range of human malignancies. BRCAA1 also interacts with RBBP1/ARID4A and regulates genomic imprinting at the Prader-WIlli syndrome (PWS)/Angelman syndrome (AS) domain.

NCBI and Uniprot Product Information

• NCBI GI #: 332164768
• NCBI GeneID: 51742
• NCBI Accession #: NP_001193723.1
• NCBI GenBank Nucleotide #: NP_001193723.1
• UniProt Accession #: Q4LE39
• NCBI Official Full Name: AT-rich interactive domain-containing protein 4B isoform 1
• NCBI Official Synonym Full Names: AT-rich interaction domain 4B
• NCBI Official Symbol: ARID4B
• NCBI Official Synonym Symbols: BCAA; BRCAA1; RBP1L1; SAP180; RBBP1L1
• NCBI Protein Information: AT-rich interactive domain-containing protein 4B
• UniProt Protein Name: AT-rich interactive domain-containing protein 4B
• UniProt Gene Name: ARID4B
• UniProt Synonym Gene Names: BRCAA1; RBBP1L1; RBP1L1; SAP180; ARID domain-containing protein 4B
• UniProt Entry Name: ARI4B_HUMAN

NCBI Description

This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]