ALOX15 blocking peptide
ALOX15 Antibody (C-term) Blocking Peptide
Gene Names
ALOX15; 12-LOX; 15LOX-1; 15-LOX-1
Synonyms
ALOX15; ALOX15 Antibody (C-term) Blocking Peptide; Arachidonate 15-lipoxygenase; 15-LOX; 15-LOX-1; 12/15-lipoxygenase; Arachidonate 12-lipoxygenase; leukocyte-type; 12-LOX; Arachidonate omega-6 lipoxygenase; LOG15; ALOX15 blocking peptide
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human ALOX15. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
662
Cellular Location
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Lipid droplet. Note: Predominantly cytosolic; becomes enriched at membranes upon calcium binding Translocates from the cytosol to the plasma membrane when stimulated by IL13/interleukin-13 and in macrophages binding apoptotic cells
Tissue Location
Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for ALOX15 blocking peptide
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12- hydroperoxyeicosatetraenoic acid/12-HPETE and 15- hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
70,108 Da
NCBI Official Full Name
Arachidonate 15-lipoxygenase
NCBI Official Synonym Full Names
arachidonate 15-lipoxygenase
NCBI Official Symbol
ALOX15
NCBI Official Synonym Symbols
12-LOX; 15LOX-1; 15-LOX-1
NCBI Protein Information
arachidonate 15-lipoxygenase
UniProt Protein Name
Arachidonate 15-lipoxygenase
UniProt Gene Name
ALOX15
UniProt Synonym Gene Names
LOG15; 12-LOX
UniProt Entry Name
LOX15_HUMAN
Uniprot Description
ALOX15: Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid. Also acts on C-12 of arachidonate as well as on linoleic acid. Belongs to the lipoxygenase family.
Protein type: Motility/polarity/chemotaxis; EC 1.13.11.33; Oxidoreductase; Lipid Metabolism - linoleic acid; Lipid Metabolism - arachidonic acid; EC 1.13.11.31
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component: cytosol; extrinsic to internal side of plasma membrane; lipid particle; membrane; plasma membrane
Molecular Function: arachidonate 12-lipoxygenase activity; arachidonate 15-lipoxygenase activity; iron ion binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding
Biological Process: apoptotic cell clearance; arachidonic acid metabolic process; bone mineralization; hepoxilin biosynthetic process; inflammatory response; leukotriene metabolic process; lipoxygenase pathway; negative regulation of adaptive immune response; ossification; phosphatidylethanolamine biosynthetic process; positive regulation of actin filament polymerization; wound healing
Research Articles on ALOX15
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Product Notes
The ALOX15 alox15 (Catalog #AAA9227362) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ALOX15, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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