ALDH1A3 blocking peptide

ALDH1A3 Blocking Peptide

Cat. Num. AAA9628208

• Gene Names: ALDH1A3; ALDH6; RALDH3; ALDH1A6
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: ALDH1A3; ALDH1A3 Blocking Peptide; Acetaldehyde dehydrogenase 6; AL1A3_HUMAN; Aldehyde dehydrogenase 1A3; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; Aldh1a3; ALDH1A6; ALDH6; RALDH 3; Retinaldehyde dehydrogenase 3; V1; ALDH1A3 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for ALDH1A3 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ALDH1A3 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 153266822
• NCBI GeneID: 220
• NCBI Accession #: NP_000684.2
• NCBI GenBank Nucleotide #: NM_000693.3
• UniProt Accession #: P47895; Q6NT64
• Molecular Weight: 56,108 Da
• NCBI Official Full Name: aldehyde dehydrogenase family 1 member A3
• NCBI Official Synonym Full Names: aldehyde dehydrogenase 1 family, member A3
• NCBI Official Symbol: ALDH1A3
• NCBI Official Synonym Symbols: ALDH6; RALDH3; ALDH1A6
• NCBI Protein Information: aldehyde dehydrogenase family 1 member A3; RALDH-3; OTTHUMP00000194835; aldehyde dehydrogenase 6; acetaldehyde dehydrogenase 6; retinaldehyde dehydrogenase 3
• UniProt Protein Name: Aldehyde dehydrogenase family 1 member A3
• Protein Family: Aldehyde dehydrogenase family
• UniProt Gene Name: ALDH1A3
• UniProt Synonym Gene Names: ALDH6; RALDH-3; RalDH3
• UniProt Entry Name: AL1A3_HUMAN

NCBI Description

Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme encoded by this gene uses retinal as a substrate, either in a free or cellular retinol-binding protein form. [provided by RefSeq]

Uniprot Description

ALDH1A3: Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system. Belongs to the aldehyde dehydrogenase family.

Protein type: Oxidoreductase; Amino Acid Metabolism - histidine; Xenobiotic Metabolism - metabolism by cytochrome P450; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 1.2.1.5; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - phenylalanine

Chromosomal Location of Human Ortholog: 15q26.3

Cellular Component: cytoplasm; cytosol

Molecular Function: aldehyde dehydrogenase (NAD) activity; protein homodimerization activity; aldehyde dehydrogenase [NAD(P)+] activity; retinal dehydrogenase activity

Biological Process: inner ear morphogenesis; retinal metabolic process; righting reflex; embryonic eye morphogenesis; retinol metabolic process; positive regulation of apoptosis; olfactory pit development; retinoic acid metabolic process; optic cup morphogenesis involved in camera-type eye development; locomotory behavior; neuromuscular process controlling balance; nucleus accumbens development

Disease: Microphthalmia, Isolated 8