SDS-PAGE
Aldehyde dehydrogenase family 1 member A3 (ALDH1A3) Recombinant Protein | ALDH1A3 recombinant protein
Recombinant Human Aldehyde dehydrogenase family 1 member A3 (ALDH1A3)
SDS-PAGE
SDS-PAGE
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an aldehyde dehydrogenase enzyme that uses retinal as a substrate. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Uniprot Description
ALDH1A3: Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system. Belongs to the aldehyde dehydrogenase family.
Protein type: Xenobiotic Metabolism - drug metabolism - cytochrome P450; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Amino Acid Metabolism - histidine; EC 1.2.1.5; Xenobiotic Metabolism - metabolism by cytochrome P450; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - phenylalanine; Oxidoreductase
Chromosomal Location of Human Ortholog: 15q26.3
Cellular Component: cytoplasm; cytosol
Molecular Function: aldehyde dehydrogenase (NAD) activity; protein homodimerization activity; aldehyde dehydrogenase [NAD(P)+] activity; retinal dehydrogenase activity
Biological Process: inner ear morphogenesis; retinal metabolic process; retinol metabolic process; embryonic eye morphogenesis; positive regulation of apoptosis; righting reflex; olfactory pit development; retinoic acid metabolic process; optic cup morphogenesis involved in camera-type eye development; locomotory behavior; neuromuscular process controlling balance; nucleus accumbens development
Disease: Microphthalmia, Isolated 8
Research Articles on ALDH1A3
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Product Notes
The ALDH1A3 aldh1a3 (Catalog #AAA963982) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-512aa; Full Length. The amino acid sequence is listed below: ATANGAVENG QPDRKPPALP RPIRNLEVKF TKIFINNEWH ESKSGKKFAT CNPSTREQIC EVEEGDKPDV DKAVEAAQVA FQRGSPWRRL DALSRGRLLH QLADLVERDR ATLAALETMD TGKPFLHAFF IDLEGCIRTL RYFAGWADKI QGKTIPTDDN VVCFTRHEPI GVCGAITPWN FPLLMLVWKL APALCCGNTM VLKPAEQTPL TALYLGSLIK EAGFPPGVVN IVPGFGPTVG AAISSHPQIN KIAFTGSTEV GKLVKEAASR SNLKRVTLEL GGKNPCIVCA DADLDLAVEC AHQGVFFNQG QCCTAASRVF VEEQVYSEFV RRSVEYAKKR PVGDPFDVKT EQGPQIDQKQ FDKILELIES GKKEGAKLEC GGSAMEDKGL FIKPTVFSEV TDNMRIAKEE IFGPVQPILK FKSIEEVIKR ANSTDYGLTA AVFTKNLDKA LKLASALESG TVWINCYNAL YAQAPFGGFK MSGNGRELGE YALAEYTEVK TVTIKLGDKN P. It is sometimes possible for the material contained within the vial of "Aldehyde dehydrogenase family 1 member A3 (ALDH1A3), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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