BRUCE Blocking Peptide | BIRC6 blocking peptide

BRUCE Peptide

Cat. Num. AAA152301

• Gene Names: BIRC6; BRUCE; APOLLON
• Applications: Blocking (BL)
• Synonyms: BRUCE; BRUCE Peptide; APOLLON; KIAA1289; Baculoviral IAP repeat-containing protein 6; BIR repeat-containing ubiquitin-conjugating enzyme; baculoviral IAP repeat-containing protein 6; BIRC6 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 4857

• Applicable Applications for BIRC6 blocking peptide: Blocking (BL)
• Application Notes: BRUCE peptide is used for blocking the activity of BRUCE antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 17 amino acid peptide near the carboxy terminus of human BRUCE.
• Preparation and Storage: Store BRUCE peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 153792694
• NCBI GeneID: 57448
• NCBI Accession #: NP_057336
• NCBI GenBank Nucleotide #: NM_016252.3
• UniProt Accession #: Q9NR09; Q9ULD1
• Molecular Weight: 530,255 Da
• NCBI Official Full Name: baculoviral IAP repeat-containing protein 6
• NCBI Official Synonym Full Names: baculoviral IAP repeat containing 6
• NCBI Official Symbol: BIRC6
• NCBI Official Synonym Symbols: BRUCE; APOLLON
• NCBI Protein Information: baculoviral IAP repeat-containing protein 6; baculoviral IAP repeat-containing 6; ubiquitin-conjugating BIR domain enzyme apollon; ubiquitin-conjugating BIR-domain enzyme apollon; BIR repeat-containing ubiquitin-conjugating enzyme
• UniProt Protein Name: Baculoviral IAP repeat-containing protein 6
• Protein Family: Baculoviral IAP repeat-containing protein
• UniProt Gene Name: BIRC6
• UniProt Synonym Gene Names: KIAA1289; BRUCE; APOLLON
• UniProt Entry Name: BIRC6_HUMAN

NCBI Description

This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]

Uniprot Description

BIRC6: Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41, DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8. Expressed in brain cancer cells. Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9.

Protein type: EC 6.3.2.19; EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 2p22.3

Cellular Component: spindle pole; membrane; microtubule organizing center; midbody; trans-Golgi network; endosome

Molecular Function: protein binding; ubiquitin-protein ligase activity; cysteine protease inhibitor activity; ligase activity

Biological Process: mitosis; apoptosis; cell division; positive regulation of cell proliferation; protein ubiquitination; regulation of cytokinesis; protein amino acid phosphorylation; regulation of cell proliferation; negative regulation of apoptosis