Human Baculoviral IAP repeat-containing protein 6 ELISA Kit | BIRC6 elisa kit

Human Baculoviral IAP repeat-containing protein 6 ELISA Kit

Cat. Num. AAA2884318

• Gene Names: BIRC6; BRUCE; APOLLON
• Reactivity: Human
• Synonyms: Baculoviral IAP repeat-containing protein 6; Human Baculoviral IAP repeat-containing protein 6 ELISA Kit; Ubiquitin-conjugating BIR domain enzyme apollon; BIRC6; KIAA1289; 6.3.2.-; BRUCE; BIRC6 elisa kit

• Reactivity: Human
• Sequence Length: 4857

• Assay Type: Sandwich
• Detection Range: 0.156-10 ng/mL
• Sensitivity: 0.056ng/mL
• Intra-Assay CV: <=3.3%
• Inter-Assay CV: <=7.2%
• Recovery: 89%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 153792694
• NCBI GeneID: 57448
• NCBI Accession #: NP_057336.3
• NCBI GenBank Nucleotide #: NM_016252.3
• UniProt Accession #: Q9NR09; Q9ULD1
• Molecular Weight: 530,255 Da
• NCBI Official Full Name: baculoviral IAP repeat-containing protein 6
• NCBI Official Synonym Full Names: baculoviral IAP repeat containing 6
• NCBI Official Symbol: BIRC6
• NCBI Official Synonym Symbols: BRUCE; APOLLON
• NCBI Protein Information: baculoviral IAP repeat-containing protein 6
• UniProt Protein Name: Baculoviral IAP repeat-containing protein 6
• Protein Family: Baculoviral IAP repeat-containing protein
• UniProt Gene Name: BIRC6
• UniProt Synonym Gene Names: KIAA1289; BRUCE; APOLLON
• UniProt Entry Name: BIRC6_HUMAN

NCBI Description

This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]

Uniprot Description

BIRC6: Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41, DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8. Expressed in brain cancer cells. Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9.

Protein type: EC 6.3.2.19; EC 6.3.2.-; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 2p22.3

Cellular Component: endosome; membrane; microtubule organizing center; midbody; spindle pole; trans-Golgi network

Molecular Function: cysteine protease inhibitor activity; ligase activity; protein binding; ubiquitin-protein ligase activity

Biological Process: apoptosis; cell division; mitosis; negative regulation of apoptosis; positive regulation of cell proliferation; protein amino acid phosphorylation; protein ubiquitination; regulation of cell proliferation; regulation of cytokinesis