Immunohistochemistry (IHC)
(Immunohistochemistry of BRUCE in human small intestine tissue with BRUCE antibody at 5 ug/ml.)
Rabbit anti-Human BRUCE Polyclonal Antibody | anti-BRUCE antibody
BRUCE Antibody
Immunohistochemistry (IHC)
(Immunohistochemistry of BRUCE in human small intestine tissue with BRUCE antibody at 5 ug/ml.)
Immunohistochemistry (IHC)
(Immunohistochemistry of BRUCE in human small intestine tissue with BRUCE antibody at 5 ug/ml.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]
Uniprot Description
BIRC6: Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41, DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8. Expressed in brain cancer cells. Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9.
Protein type: Ubiquitin ligase; EC 6.3.2.19; Ubiquitin conjugating system; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 2p22.3
Cellular Component: spindle pole; membrane; microtubule organizing center; trans-Golgi network; midbody; endosome
Molecular Function: protein binding; ubiquitin-protein ligase activity; cysteine protease inhibitor activity; ligase activity
Biological Process: mitosis; cell division; apoptosis; positive regulation of cell proliferation; protein ubiquitination; regulation of cytokinesis; protein amino acid phosphorylation; regulation of cell proliferation; negative regulation of apoptosis
Research Articles on BRUCE
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Product Notes
The BRUCE birc6 (Catalog #AAA9404497) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The BRUCE Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's BRUCE can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the BRUCE birc6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BRUCE, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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