Chemical Structure
sbp-7455, inhibitor
sbp-7455
Purity
0.9903
Synonyms
sbp-7455; inhibitor
Purity/Purification
0.9903
Form/Format
Solid
Solubility
DMSO: 120mg/mL (338.67mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
SMILES
COC1=C(OC)C=CC(NC2=NC(NC3CC3)=C(C(F)(F)F)C=N2)=C1
Formula
C16H17F3N4O2
In vitro
To evaluate the PD profile and in vivo target engagement, mice were dosed with SBP-7455 (10 mg/kg) or vehicle by oral gavage, and liver samples were collected after 2 h.Based on the PK and PD profiles, our data show that SBP-7455 is an efficacious tool that can be used to modulate autophagy in vivop[1].
CAS Number
1884222-74-5
Preparation and Storage
Store at 0-4 degree C for short term (days to weeks), or -20 degree C for long term (months).
Chemical Structure
Chemical Structure
Related Product Information for sbp-7455, inhibitor
SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.
References
Ren H, Bakas NA, Vamos M, et al. Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2020;63(23):14609-14625. doi:10.1021/acs.jmedchem.0c00873
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Product Notes
The sbp-7455 (Catalog #AAA5765008) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "sbp-7455, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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