Structure
TP455 Biochemical
TP455
Purity
>98% (HPLC)
Synonyms
TP455; TP-455; TP 455; TP455 biochemical
Purity/Purification
>98% (HPLC)
Target
Adenosine Receptor
Receptor
Adenosine Receptor
Chemical Name
2-(2-furanyl)-N5-(2-methoxybenzyl)[1, 3]thiazolo[5, 4-d]pyrimidine-5, 7-diammine
SMILES
COC1=CC=CC=C1CNC2=NC(=C3C(=N2)SC(=N3)C4=CC=CO4)N
Molecular Formula
C17H15N5O2S
CAS Number
2042563-95-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for TP455 biochemical
TP455 (TP-455) is a highly potent, selective A2A adenosine receptor inverse agonist with IC50 of 1.9nM in cyclic AMP assays in hA2A CHO cells; TP455 proved to be more potent than morphine in writhing and tail immersion tests in mice with ED50 of 0.0328mg/kg, exhibits great analgesic activity with an ED50 of 0.134 +/- 0.011mg/kg and minimum effective dose of 0.01mg/kg; antagonizes CGS 21680-induced cell proliferation in cancer cell lines, inhibits GS 21680-dependent pERK1/2, pJNK MAPK kinase, and pAKT activation.
Product Categories/Family for TP455 biochemical
References
1. Gessi S, et al. Front Pharmacol. 2017 Dec 1; 8:888. doi: 10.3389/fphar.2017.00888.
2. Varano F, et al. J Med Chem. 2016 Dec 8; 59 (23):10564-10576.
2. Varano F, et al. J Med Chem. 2016 Dec 8; 59 (23):10564-10576.
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Product Notes
The TP455 (Catalog #AAA3603178) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "TP455, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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