Structure
BYK191023, Inhibitor
BYK191023
Purity
>98% (HPLC)
Synonyms
BYK191023; BYK-191023; inhibitor
Purity/Purification
>98% (HPLC)
Target
NOS
Receptor
NOS
Chemical Name
2-[2-(4-Methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4, 5-b]pyridine
SMILES
COC1=CC(=NC=C1)CCC2=NC3=C(N2)C=CC=N3
Molecular Formula
C14H14N4O
CAS Number
608880-48-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for BYK191023, inhibitor
BYK191023 (BYK-191023) is a potent, highly selective inhibitor of inducible nitric-oxide synthase (iNOS) with IC50 of 86nM, >20-fold selectivity over nNOS and eNOS (IC50=17 and 162uM); exhibits an affinity for iNOS, nNOS, and eNOS of 450nM, 30uM, and >500uM, respectively; inhibits cellular nitrate/nitrite synthesis in RAW, rat mesangium, and human embryonic kidney 293 cells with IC50 values 40- to 100-fold higher than at the isolated enzyme; dose-dependently suppresses the LPS-induced increase in plasma nitrate/nitrite (NO (x)) levels with ED50 of 14.9 micromol/kg/h, partially restores normal blood pressure responses to norepinephrine and sodium nitroprusside in model of LPS-induced vascular hyporesponsiveness.
Product Categories/Family for BYK191023, inhibitor
References
1. Strub A, et al. Mol Pharmacol. 2006 Jan; 69 (1):328-37.
2. Lehner MD, et al. J Pharmacol Exp Ther. 2006 Apr; 317 (1):181-7.
3. Tiso M, et al. Mol Pharmacol. 2008 Apr; 73 (4):1244-53.
4. Higashi Y, et al. Br J Pharmacol. 2018 Jul 14. doi: 10.1111/bph.14445.
2. Lehner MD, et al. J Pharmacol Exp Ther. 2006 Apr; 317 (1):181-7.
3. Tiso M, et al. Mol Pharmacol. 2008 Apr; 73 (4):1244-53.
4. Higashi Y, et al. Br J Pharmacol. 2018 Jul 14. doi: 10.1111/bph.14445.
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Product Notes
The BYK191023 (Catalog #AAA3605285) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BYK191023, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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