Structure
ONC-201 biochemical
ONC-201
Purity
>=98%
Synonyms
ONC-201; 11-benzyl-7-[(2-methylphenyl)methyl]-2; 5; 7; 11-tetrazatricyclo[7.4.0.02; 6]trideca-1(9); 5-dien-8-one; 7-Benzyl-4-(2-methylbenzyl)-1; 2; 6; 8; 9-hexahydroimidazo[1; 2-A]pyrido[3; 4-E]pyrimidin-5(4H)-one; 4; 9-hexahydro-4-[(2-methylphenyl)methyl]-7-(phenylmethyl)-imidazo[1; 2-a]pyrido[3; 4-e]pyrimidin-5(1H)-one; TIC10; TRAIL-inducing compound 10; ONC-201 biochemical
Specificity
A transcriptional inducer of TRAIL
Purity/Purification
>=98%
Form/Format
White to off-white powder
Solubilities
~20mg/ml in DMF; ~10mg/ml in ethanol; ~1mg/ml in DMSO
Molecular Formula
C??H??N?O
InChi
InChI=1S/C24H26N4O/c1-18-7-5-6-10-20(18)16-28-23(29)21-17-26(15-19-8-3-2-4-9-19)13-11-22(21)27-14-12-25-24(27)28/h2-10H; 11-17H2; 1H3
InChi Key
VLULRUCCHYVXOH-UHFFFAOYSA-N
SMILES
CC1=CC=CC=C1CN2C(=O)C3=C(CCN(C3)CC4=CC=CC=C4)N5C2=NCC5CC1=CC=CC=C1CN2C(=O)C3=C(CCN(C3)CC4=CC=CC=C4)N5C2=NCC5
CAS Number
1616632-77-9
MDL Number
MFCD28118993
PubChem CID
73777259
Preparation and Storage
Store at -20 degree C
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shelf Life: Est.~36 months
Country of Origin: USA
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shelf Life: Est.~36 months
Country of Origin: USA
Structure
Structure
Related Product Information for ONC-201 biochemical
ONC-201 is an orally active transcriptional inducer of Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). It induces TRAIL in a p53-independent manner at concentrations of 1.25uM-5uM and crosses the blood-brain barrier. It inactivates kinases Akt and extracellular signal-regulated kinase (ERK), leading to the translocation of Foxo3a into the nucleus, where it binds to the TRAIL promoter to up-regulate gene transcription. It causes tumor regression in HCT116 p53-/- xenograft bearing mice.
Product Categories/Family for ONC-201 biochemical
References
https://pubchem.ncbi.nlm.nih.gov/compound/73777259
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Product Notes
The ONC-201 (Catalog #AAA8400515) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ONC-201, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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