Structure
NSC 19630 Biochemical
NSC 19630
Purity
>98% (HPLC)
Synonyms
NSC 19630; MIRA-1; NSC 19630 biochemical
Purity/Purification
>98% (HPLC)
Target
DNA Repair Protein
Receptor
DNA Repair Protein
Chemical Name
1-[(1-oxopropoxy)methyl]-1H-pyrrole-2, 5-dione
SMILES
O=C(C=C1)N(COC(CC)=O)C1=O
Molecular Formula
C8H9NO4
CAS Number
72835-26-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for NSC 19630 biochemical
NSC 19630 (MIRA-1) is a potent, selective Werner syndrome helicase (WRN helicase) with IC50 of 20uM; shows selecitvity over human RecQ helicases (RECQ1 and BLM), Fanconi anemia group J (FANCJ) helicases and three Escherichia coli helicases (RecQ, UvrD, and DnaB); dramatically impaires growth and proliferation, induces apoptosis in a WRN-dependent manner, and resultes in elevated gamma-H2AX and PCNA foci in human cells; delays S-phase progression and induces DNA damage; a mutant p53 reactivator that induces mutant p53-dependent cell death in different human tumor cells carrying tetracycline-regulated mutant p53.
Product Categories/Family for NSC 19630 biochemical
References
1. Aggarwal M, et al. Proc Natl Acad Sci U S A. 2011 Jan 25; 108 (4):1525-30.
2. Saha MN, et al. Br J Cancer. 2014 Apr 29; 110 (9):2224-31.
3. Bykov VJ, et al. J Biol Chem. 2005 Aug 26; 280 (34):30384-91.
2. Saha MN, et al. Br J Cancer. 2014 Apr 29; 110 (9):2224-31.
3. Bykov VJ, et al. J Biol Chem. 2005 Aug 26; 280 (34):30384-91.
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Product Notes
The NSC 19630 (Catalog #AAA3605785) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NSC 19630, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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