Structure
IRES-C11, Inhibitor
IRES-C11
Purity
>98% (HPLC)
Synonyms
IRES-C11; IRES inhibitor C11; inhibitor
Purity/Purification
>98% (HPLC)
Target
c-Myc
Receptor
c-Myc
Chemical Name
3, 4-dichloro-1-(2, 4-dimethoxybenzyl)-1H-pyrrole-2, 5-dione
SMILES
COC1=CC(=C(C=C1)CN2C(=O)C(=C(C2=O)Cl)Cl)OC
Molecular Formula
C13H11Cl2NO4
CAS Number
342416-30-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for IRES-C11, inhibitor
A novel, spectfic c-Myc IRES (internal ribosome entry site) function inhibitor that prevents binding of hnRNP A1 to the Myc IRES and specifically inhibits Myc IRES activity in MM cells; shows no effect on BAG-1, XIAP and p53 IRESes, and has no significant effect on myc translation; significantly inhibits myc expression when combined with ER stress inducers, especially bortezomib; shows synergistic anti-MM cytotoxicity combined with ER stress inducers; also blocks cyclin D1 IRES-dependent initiation and demonstrates synergistic anti-GBM properties combined with PP242.
Product Categories/Family for IRES-C11, inhibitor
References
1. Shi Y, et al. Oncogene. 2016 Feb 25; 35 (8):1015-24.
2. Holmes B, et al. J Biol Chem. 2016 Jul 1; 291 (27):14146-59.
2. Holmes B, et al. J Biol Chem. 2016 Jul 1; 291 (27):14146-59.
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Product Notes
The IRES-C11 (Catalog #AAA3604163) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "IRES-C11, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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