Structure
LY 2812223 Biochemical
LY 2812223
Purity
>98% (HPLC)
Synonyms
LY 2812223; LY2812223; LY-2812223; LY 2812223 biochemical
Purity/Purification
>98% (HPLC)
Target
mGluR
Receptor
mGluR
Chemical Name
(1R, 2S, 4R, 5R, 6R)-2-amino-4-(1H-1, 2, 4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2, 6-dicarboxylic acid
SMILES
[H][C@]12[C@]([C@H]2C(O)=O)([H])[C@@](C(O)=O)(N)C[C@H]1SC3=NNC=N3
CAS Number
1311385-20-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for LY 2812223 biochemical
A highly potent, functionally selectivemglu2 receptor agonist with EC50 of 13.6nM in GTPgammaS functional binding assay; displays little to no affinity formglu1,mglu4,mglu5 ormglu7 receptors; fully displaces themglu2/3 agonist radioligand [3H]LY459477 with Ki of 118nM, inhibits forskolin-stimulated cAMP with EC50 of 16.1nM; displays near maximal agonist responses at themglu2 receptor across all assay formats, while shows no functional agonist activity at themglu3 receptor except in the cAMP assay. Alzheimer Disease Phase 2 Clinical
Product Categories/Family for LY 2812223 biochemical
References
1. Monn JA, et al. J Med Chem. 2015 Sep 24; 58 (18):7526-48.
2. Felder CC, et al. J Pharmacol Exp Ther. 2017 Apr; 361 (1):190-197.
2. Felder CC, et al. J Pharmacol Exp Ther. 2017 Apr; 361 (1):190-197.
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Product Notes
The LY 2812223 (Catalog #AAA3601252) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LY 2812223, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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