Structure
Xanomeline oxalate Biochemical
Xanomeline oxalate
Purity
>98% (HPLC)
Synonyms
Xanomeline oxalate; LY246708; LY-246708; NNC 110232; Xanomeline oxalate biochemical
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
mAChR
Receptor
mAChR
Chemical Name
Pyridine, 3-[4-(hexyloxy)-1, 2, 5-thiadiazol-3-yl]-1, 2, 5, 6-tetrahydro-1-methyl-, ethanedioate(1:1)
SMILES
CCCCCCOC1=NSN=C1C2=CCCN(C2)C.C(=O)(C(=O)O)O
Molecular Formula
C16H25N3O5S
CAS Number
141064-23-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Xanomeline oxalate biochemical
Xanomeline oxalate (LY246708, NNC 110232) is a potent, specific M1 muscarinic agonist with functional selectivity for M1 receptor (binding IC50 of 6 pM in the rabbit vas deferens); displays low affinity for M2 receptors in guinea pig atria (EC50=3uM); xanomeline increases striatal levels of dopamine metabolites, presumably by acting at M1 heteroreceptors on dopamine neurons to increase dopamine release in vivo; inhibits ex vivo binding of muscarinic radioligands to homogenates of brain and the inhibition of ex vivo binding occurred in the same dose range as increases in DOPAC levels; xanomeline is selective agonist for M1 over M2 and M3 receptors in vivo in rats. Alzheimer Disease Phase 3 Discontinued
Product Categories/Family for Xanomeline oxalate biochemical
References
1. Shannon HE, et al. J Pharmacol Exp Ther. 1994 Apr; 269 (1):271-81.
2. Sauerberg P, et al. J Med Chem. 1992 Jun 12; 35 (12):2274-83.
3. Bymaster FP, et al. J Pharmacol Exp Ther. 1994 Apr; 269 (1):282-9.
2. Sauerberg P, et al. J Med Chem. 1992 Jun 12; 35 (12):2274-83.
3. Bymaster FP, et al. J Pharmacol Exp Ther. 1994 Apr; 269 (1):282-9.
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Product Notes
The Xanomeline oxalate (Catalog #AAA3601712) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Xanomeline oxalate, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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