Structure
LRRK2-IN-1 Biochemical
LRRK2-IN-1
Purity
0.9938
Synonyms
LRRK2-IN-1; 5; 11-dihydro-2-[[2-methoxy-4-[[4- (4-methyl-1-piperazinyl)- 1-piperidinyl]carbonyl] phenyl]amino]- 5; 11-dimethyl-6H-pyrimido[4; 5-b][1; 4] benzodiazepin-6-one; 2-[2-methoxy-4-[4- (4-methylpiperazin-1-yl) piperidine-1-carbonyl]anilino]-5; 11-dimethylpyrimido[4; 4]benzodiazepin-6-one; Leucine-rich repeat kinase 2 IN-1; LRRK2IN1; LRRK2-IN-1 biochemical
Purity/Purification
0.9938
Form/Format
A crystalline solid
Solubility
~25 mg/ml in Ethanol
~20 mg/ml in DMF
~16 mg/ml in DMSO
~20 mg/ml in DMF
~16 mg/ml in DMSO
Molecular Formula
C??H??N?O?
CAS Number
1234480-84-2
PubChem CID
46843906
SMILES
CN1CCN (CC1)C2CCN (CC2)C (=O)C3=CC (=C (C=C3)NC4=NC=C5C (=N4)N (C6=CC=CC=C6C (=O)N5C)C)OC
InChi
InChI=1S/C31H38N8O3/c1-35-15-17-38 (18-16-35)22-11-13-39 (14-12-22)29 (40)21-9-10-24 (27 (19-21)42-4)33-31-32-20-26-28 (34-31)36 (2)25-8-6-5-7-23 (25)30 (41)37 (26)3/h5-10,19-20,22H,11-18H2,1-4H3, (H,32,33,34)
InChi Key
IWMCPJZTADUIFX-UHFFFAOYSA-N
Preparation and Storage
Store at -20 degree C
Shelf life: ~36 months
Shelf life: ~36 months
Structure
Structure
Related Product Information for LRRK2-IN-1 biochemical
LRRK2-IN-1 is a potent inhibitor of Leucine-rich repeat kinase 2 (LRRK2). Mutations in LRRK2 are associated with Parkinson's disease. LRRK2-IN-1 inhibits wild-type and G2019S mutant LRRK2 with IC50 values of 13 nM and 6 nM, respectively. It suppresses LRRK2 kinase activity in vivo leading to dephosphorylation of Ser910/Ser935, loss of 14-3-3 binding and accumulation of LRRK2 within aggregate structures. It stimulates autophagy in H4 neuroglioma cells.
Product Categories/Family for LRRK2-IN-1 biochemical
References
https://pubchem.ncbi.nlm.nih.gov/compound/46843906
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Product Notes
The LRRK2-IN-1 (Catalog #AAA849035) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LRRK2-IN-1, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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