Structure
NMS-1286937 Biochemical
NMS-1286937
Purity
>=98% by HPLC
Synonyms
NMS-1286937; NMS1286937; 1- (2-hydroxyethyl)-8-[5- (4-methylpiperazin-1-yl)-2- (trifluoromethoxy) anilino]-4; 5-dihydropyrazolo[4; 3-h]quinazoline-3-carboxamide; NMS-1286937 biochemical
Purity/Purification
>=98% by HPLC
Form/Format
Crystalline solid
Solubility
>20 mg/ml in DMSO
Molecular Formula
C??H??F?N?O?
CAS Number
1034616-18-6
PubChem CID
49792852
SMILES
CN1CCN (CC1)C2=CC (=C (C=C2)OC (F)(F)F)NC3=NC=C4CCC5=C (C4=N3)N (N=C5C (=O)N)CCO
InChi
InChI=1S/C24H27F3N8O3/c1-33-6-8-34 (9-7-33)15-3-5-18 (38-24 (25,26)27)17 (12-15)30-23-29-13-14-2-4-16-20 (22 (28)37)32-35 (10-11-36)21 (16)19 (14)31-23/h3,5,12-13,36H,2,4,6-11H2,1H3, (H2,28,37)(H,29,30,31)
InChi Key
QHLVBNKYJGBCQJ-UHFFFAOYSA-N
Preparation and Storage
Store at -20 degree C
Shelf life: ~36 months
Shelf life: ~36 months
Structure
Structure
Related Product Information for NMS-1286937 biochemical
NMS-1286937 a potent, small-molecule Polo-like kinase 1 (PLK1) inhibitor (IC50 = 2 nM) with potential antineoplastic activity. It selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells.
Product Categories/Family for NMS-1286937 biochemical
References
https://pubchem.ncbi.nlm.nih.gov/compound/49792852
Similar Products
Product Notes
The NMS-1286937 (Catalog #AAA848904) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NMS-1286937, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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