Structure
JNJ-39393406 Biochemical
JNJ-39393406
Purity
>98% (HPLC)
Synonyms
JNJ-39393406; JNJ39393406; JNJ-39393406 biochemical
Purity/Purification
>98% (HPLC)
Target
nAChR
Receptor
nAChR
Chemical Name
1H-1, 2, 4-Triazole-1-propanamide, 3-[(2, 2-difluoro-1, 3-benzodioxol-5-yl)amino]-N, N-dimethyl-5-(4-pyridinyl)
SMILES
O=C(N(C)C)CCN1N=C(NC2=CC=C(OC(F)(F)O3)C3=C2)N=C1C4=CC=NC=C4
Molecular Formula
C19H18F2N6O3
CAS Number
953428-73-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for JNJ-39393406 biochemical
JNJ-39393406 is a potent, selective positive allosteric alpha7 nAChR modulator, potentiates a 100uM choline-induced rise in intracellular calcium mediated by human alpha7 channels expressed in GH4C1 cells with EC50 of 660nM; does not act on alpha4beta2, alpha3beta4 or 5-HT3A channels, as well as alpha4beta2, alpha3beta4 or 5 HT3A channels, and it does not interacts with a panel of 62 receptors and enzymes; shows bell-shaped dose-response activity in the auditory evoked potential (AEP) in DBA2 mice (0.63-5mg/kg s. C., lower and higher doses were inactive), and model for sensory gating and the attentional set-shifting in rats. Depression Phase 2 Clinical
Product Categories/Family for JNJ-39393406 biochemical
References
1. Winterer G, et al. Neuropharmacology. 2013 Jan; 64:197-204.
2. Perkins KA, et al. Neuropsychopharmacology. 2018 May; 43 (6):1334-1342.
2. Perkins KA, et al. Neuropsychopharmacology. 2018 May; 43 (6):1334-1342.
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Product Notes
The JNJ-39393406 (Catalog #AAA3606807) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "JNJ-39393406, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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