Structure
JNJ-42165279, Inhibitor
JNJ-42165279
Purity
>98% (HPLC)
Synonyms
JNJ-42165279; JNJ42165279; JNJ 42165279; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
FAAH
Receptor
hFAAH; rFAAH
Chemical Name
1-Piperazinecarboxamide, N-(4-chloro-3-pyridinyl)-4-[(2, 2-difluoro-1, 3-benzodioxol-5-yl)methyl]
SMILES
C1CN(CCN1CC2=CC3=C(C=C2)OC(O3)(F)F)C(=O)NC4=C(C=CN=C4)Cl
Molecular Formula
C18H17ClF2N4O3
CAS Number
1346528-50-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for JNJ-42165279, inhibitor
JNJ-42165279 is a highly selective inhibitor of fatty acid amide hydrolase (FAAH) with IC50 of 70nM for hFAAH; no inhibition on CYPs and hERG at 10uM; blocks FAAH in the brain and periphery of rats, causes an elevation of the concentrations of AEA, OEA, and PEA; demonstrates activity in the spinal nerve ligation (SNL) model of neuropathic pain; exhibited excellent ADME and pharmacodynamic properties. Anxiety Phase 2 Clinical
Product Categories/Family for JNJ-42165279, inhibitor
References
1. Keith JM, et al. ACS Med Chem Lett. 2015 Nov 2; 6 (12):1204-8.
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Product Notes
The JNJ-42165279 (Catalog #AAA3601398) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "JNJ-42165279, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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