Structure
JNJ-55308942 Biochemical
JNJ-55308942
Purity
>98% (HPLC)
Synonyms
JNJ-55308942; JNJ55308942; JNJ-55308942 biochemical
Purity/Purification
>98% (HPLC)
Target
P2X Receptor
Receptor
P2X Receptor
Chemical Name
(S)-(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)(1-(5-fluoropyrimidin-2-yl)-6-methyl-1, 4, 6, 7-tetrahydro-5H-[1, 2, 3]triazolo[4, 5-c]pyridin-5-yl)methanone
Molecular Formula
C17H12F5N7O
CAS Number
2166558-11-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for JNJ-55308942 biochemical
JNJ-55308942 is a novel highly potent P2X7 antagonist with Ki of 1.0 and 6.5nM for rat and human hP2X7, demonstrates significant activity against a panel of related P2X receptors (P2X1, P2X2, P2X3, P2X2/3, and P2X4; also shows insignificant inhibition of nine CYP isoforms (IC50>15uM); exhibits excellent P2X7 receptor occupancy in the hippocampus of rats with low ED50 of 0.07mg/kg and unbound plasma EC50 of 12 ng/mL, suppresses brain IL-1beta release in vivo in freely moving rats challenged with the P2X7 agonist Bz-ATP; possesses good tolerability margins in preclinical species, as well as an acceptable cardiovascular safety profile in vivo.Epilepsy Phase 1 Clinical.
Product Categories/Family for JNJ-55308942 biochemical
References
1. Chrovian CC, et al. J Med Chem. 2018 Jan 11; 61 (1):207-223.
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Product Notes
The JNJ-55308942 (Catalog #AAA3603460) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "JNJ-55308942, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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