Structure
INCB-3344 Biochemical
INCB-3344
Purity
>98% (HPLC)
Synonyms
INCB-3344; INCB 3344; INCB3344; INCB-3344 biochemical
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
Chemokine Receptor
Receptor
Chemokine Receptor
Chemical Name
Benzamide, N-[2-[[(3R, 4R)-1-[trans-4-(1, 3-benzodioxol-5-yl)-4-hydroxycyclohexyl]-4-ethoxy-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-, rel
SMILES
CCOC1CN(CC1NC(=O)CNC(=O)C2=CC(=CC=C2)C(F)(F)F)C3CCC(CC3)(C4=CC5=C(C=C4)OCO5)O
Molecular Formula
C29H34F3N3O6
CAS Number
1262238-11-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for INCB-3344 biochemical
A potent, selective and orally bioavailable CCR2 antagonist with IC50 of 5.1nM and 9.5nM for hCCR2 and mCCR2, respectively, in MCP-1 binding assay; show no significant activity for murine CCR1 and murine CCR5 (IC50>1uM), and a panel of >50 ion channels, transporters, chemokine receptors and other selected GPCRs; inhibits macrophage influx in a mouse model of delayed-type hypersensitivity, significantly reduces disease in models of multiple sclerosis, and inflammatory arthritis. Rheumatoid Arthritis Preclinical
Product Categories/Family for INCB-3344 biochemical
References
1. Brodmerkel CM, et al. J Immunol. 2005 Oct 15; 175 (8):5370-8.
2. Xue CB, et al. Bioorg Med Chem Lett. 2010 Dec 15; 20 (24):7473-8.
3. Zweemer AJ, et al. Mol Pharmacol. 2013 Oct; 84 (4):551-61.
2. Xue CB, et al. Bioorg Med Chem Lett. 2010 Dec 15; 20 (24):7473-8.
3. Zweemer AJ, et al. Mol Pharmacol. 2013 Oct; 84 (4):551-61.
Similar Products
Product Notes
The INCB-3344 (Catalog #AAA3601091) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "INCB-3344, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
