Structure
GW-4064 Biochemical
GW-4064
Purity
>98% (HPLC)
Synonyms
GW-4064; GW 4064; GW4064; GW-4064 biochemical
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
FXR
Receptor
FXR
Chemical Name
Benzoic acid, 3-[2-[2-chloro-4-[[3-(2, 6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]
SMILES
O=C(O)C1=CC=CC(/C=C/C2=CC=C(OCC3=C(C(C)C)ON=C3C4=C(Cl)C=CC=C4Cl)C=C2Cl)=C1
Molecular Formula
C28H22Cl3NO4
CAS Number
278779-30-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for GW-4064 biochemical
A potent and selective FXR agonist with EC50 of 15nM in cell-free assay, >200-fold more potent than CDCA; has an EC50 of 80 and 90nM, respectively, in CV-1 cells transfected with mouse and human FXR expression vectors; significantly reducess serum alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase, as well as other markers of liver damage in rat models of cholestasis.
Product Categories/Family for GW-4064 biochemical
References
1. Maloney PR, et al. J Med Chem. 2000 Aug 10; 43 (16):2971-4.
2. Liu Y, et al. J Clin Invest. 2003 Dec; 112 (11):1678-87.
3. Kast HR, et al. J Biol Chem. 2002 Jan 25; 277 (4):2908-15.
2. Liu Y, et al. J Clin Invest. 2003 Dec; 112 (11):1678-87.
3. Kast HR, et al. J Biol Chem. 2002 Jan 25; 277 (4):2908-15.
Similar Products
Product Notes
The GW-4064 (Catalog #AAA3603851) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GW-4064, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
