Structure
GW3965 hydrochloride Biochemical
GW3965 hydrochloride
Purity
>98% (HPLC)
Synonyms
GW3965 hydrochloride; GW 3965 hydrochloride; GW-3965 hydrochloride; GW3965 hydrochloride biochemical
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
LXR
Receptor
hLXRalpha; hLXRbeta; LXRalpha/SRC1LiSA
Chemical Name
Benzeneacetic acid, 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2, 2-diphenylethyl)amino]propoxy]-, hydrochloride(1:1)
SMILES
Cl.OC(=O)CC1=CC=CC(OCCCN(CC(C2=CC=CC=C2)C2=CC=CC=C2)CC2=CC=CC(=C2Cl)C(F)(F)F)=C1|c:6,18,20,25,27,33,35,42,t:4,16,23,31|
Molecular Formula
C33H32Cl2F3NO3
CAS Number
405911-17-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for GW3965 hydrochloride biochemical
A potent, selective, orally active LXR agonist that recruits the steroid receptor coactivator 1 to human LXRalpha in a cell-free ligand-sensing assay with an EC50 of 125nM; acts as a full agonist on hLXRalpha and hLXRbeta in cell-based reporter gene assays with EC50 of 190 and 30nM, respectively; increases expression of ABCA1 in the small intestine and peripheral macrophages in C57BL/6 mice at 10mg/kg. Asthma Discontinued
Product Categories/Family for GW3965 hydrochloride biochemical
References
1. Collins JL, et al. J Med Chem. 2002 May 9; 45 (10):1963-6.
2. Joseph SB, et al. Proc Natl Acad Sci U S A. 2002 May 28; 99 (11):7604-9.
3. Donkin JJ, et al. J Biol Chem. 2010 Oct 29; 285 (44):34144-54.
2. Joseph SB, et al. Proc Natl Acad Sci U S A. 2002 May 28; 99 (11):7604-9.
3. Donkin JJ, et al. J Biol Chem. 2010 Oct 29; 285 (44):34144-54.
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Product Notes
The GW3965 hydrochloride (Catalog #AAA3604396) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GW3965 hydrochloride, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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