Structure
Dapagliflozin (2S)-1, 2-propanediol hydrate, Inhibitor
Dapagliflozin (2S)-1, 2-propanediol hydrate
Purity
>98% (HPLC)
Synonyms
Dapagliflozin (2S)-1; 2-propanediol hydrate; BMS-512148; BMS512148; BMS 512148; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
SGLT
Receptor
SGLT2
Chemical Name
D-Glucitol, 1, 5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-, (1S)-, compd. with(2S)-1, 2-propanediol, hydrate(1:1:1)
SMILES
CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C3C(C(C(C(O3)CO)O)O)O)Cl.CC(CO)O.O
Molecular Formula
C24H35ClO9
CAS Number
960404-48-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Dapagliflozin (2S)-1, 2-propanediol hydrate, inhibitor
A potent, selective, orally active hSGLT2 inhibitor with EC50 of 1.12nM; displays >300-fold selectivity over hSGLT1 (EC50=330nM), highly selectivity versus GLUT transporters; also is a potent selective inhibitor of rSGLT2 (EC50=3nM), with 200-fold selectivity versus rSGLT1; significantly improves glucose homeostasis, reduces blood glucose levels in hyperglycemic streptozotocin (STZ) rats. Diabetes Approved
Product Categories/Family for Dapagliflozin (2S)-1, 2-propanediol hydrate, inhibitor
References
1. Meng W, et al. J Med Chem. 2008 Mar 13; 51 (5):1145-9.
2. Han S, et al. Diabetes. 2008 Jun; 57 (6):1723-9.
3. Wilson C. Nat Rev Endocrinol. 2010 Oct; 6 (10):531.
4. Komoroski B, et al. Clin Pharmacol Ther. 2009 May; 85 (5):513-9.
2. Han S, et al. Diabetes. 2008 Jun; 57 (6):1723-9.
3. Wilson C. Nat Rev Endocrinol. 2010 Oct; 6 (10):531.
4. Komoroski B, et al. Clin Pharmacol Ther. 2009 May; 85 (5):513-9.
Similar Products
Product Notes
The Dapagliflozin (2S)-1, 2-propanediol hydrate (Catalog #AAA3606853) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Dapagliflozin (2S)-1, 2-propanediol hydrate, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
