Structure
Ganaplacide Biochemical
Ganaplacide
Purity
>98% (HPLC)
Synonyms
Ganaplacide; KAF156; GNF-156; Ganaplacide biochemical
Purity/Purification
>98% (HPLC)
Target
Parasite
Receptor
Parasite
Chemical Name
2-amino-1-[3-(4-fluoroanilino)-2-(4-fluorophenyl)-8, 8-dimethyl-5, 6-dihydroimidazo[1, 2-a]pyrazin-7(8H)-yl]ethan-1-one
SMILES
CC1(C)C2=NC(C3=CC=C(F)C=C3)=C(NC4=CC=C(F)C=C4)N2CCN1C(CN)=O
Molecular Formula
C22H23F2N5O
CAS Number
1261113-96-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Ganaplacide biochemical
Ganaplacide (KAF156, GNF-156) is a novel antimalarial clinical candidate that shows blood schizonticidal activity with IC50 of 6-17.4nM against P falciparum drug-sensitive and drug-resistant strains; demonstrates potent therapeutic activity in mouse models of malaria with 50, 90, and 99% effective doses of 0.6, 0.9, and 1.4mg/kg, respectively; KAF156 is completely protective as a single oral dose of 10mg/kg in sporozoite challenge mouse model; shows the potential to treat, prevent, and block the transmission of malaria. Parasite Infection Phase 2 Clinical
Product Categories/Family for Ganaplacide biochemical
References
1. Kuhen KL, et al. Antimicrob Agents Chemother. 2014 Sep; 58 (9):5060-7.
2. Leong FJ, et al. Antimicrob Agents Chemother. 2014 Nov; 58 (11):6437-43.
3. Lim MY, et al. Nat Microbiol. 2016 Sep 19:16166.
4. White NJ, et al. N Engl J Med. 2016 Sep 22; 375 (12):1152-60.
2. Leong FJ, et al. Antimicrob Agents Chemother. 2014 Nov; 58 (11):6437-43.
3. Lim MY, et al. Nat Microbiol. 2016 Sep 19:16166.
4. White NJ, et al. N Engl J Med. 2016 Sep 22; 375 (12):1152-60.
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Product Notes
The Ganaplacide (Catalog #AAA3601081) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Ganaplacide, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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