Structure
SJ-733 Biochemical
SJ-733
Purity
>98% (HPLC)
Synonyms
SJ-733; (+)-SJ733; SJ000557733; SJ-557733; SJ-733 biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 50mg/mL (106.75mM)
Target
Parasite
Receptor
Parasite
Chemical Name
(3S, 4S)-N-(3-Cyano-4-fluorophenyl)-1-oxo-3-(3-pyridinyl)-2-(2, 2, 2-trifluoroethyl)-1, 2, 3, 4-tetrahydro-4-isoquinolinecarboxamide
SMILES
O=C([C@@H](C1=C2C=CC=C1)[C@@H](C3=CC=CN=C3)N(CC(F)(F)F)C2=O)NC4=CC=C(F)C(C#N)=C4
Molecular Formula
C24H16F4N4O2
CAS Number
1424799-20-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for SJ-733 biochemical
SJ-733 (SJ000557733; SJ-557733) is an anti-malarial compound that targets ATP4, a cation-transporting ATPase responsible for maintaining low intracellular Na (+) levels in the parasite; displays high potency in vitro against all tested strains of P. falciparum with EC50 of 10-60nM; kills parasites and the high fitness cost associated with resistance-conferring mutations appear to slow and suppress the selection of highly drug-resistant mutants in vivo; high oral bioavailabilityParasite Infection Phase 1 Clinical
Product Categories/Family for SJ-733 biochemical
References
1. Jimienez-Diaz MB, et al. Proc Natl Acad Sci U S A. 2014 Dec 16; 111 (50):E5455-62.
2. Crawford ED, et al. PLoS One. 2017 May 22; 12 (5):e0178163.
3. Mogollon CM, et al. PLoS One. 2016 Dec 20; 11 (12):e0168362.
2. Crawford ED, et al. PLoS One. 2017 May 22; 12 (5):e0178163.
3. Mogollon CM, et al. PLoS One. 2016 Dec 20; 11 (12):e0168362.
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Product Notes
The SJ-733 (Catalog #AAA3601792) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SJ-733, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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