Structure
Aminoxyrone Biochemical
Aminoxyrone
Purity
>98% (HPLC)
Synonyms
Aminoxyrone; Aminoxyrone biochemical
Purity/Purification
>98% (HPLC)
Target
HSP
Receptor
HSP
Chemical Name
benzyl(((2R, 6R, 10R, 14R, 18R, 22R)-6-benzyl-10, 14-di((S)-sec-butyl)-22-carbamoyl-18-isobutyl-24-methyl-3, 7, 11, 15, 19-pentaoxo-1-phenyl-5, 9, 13, 17, 21-pentaoxa-4, 8, 12, 16, 20-pentaazapentacosan-2-yl)oxy)carbamate
Molecular Formula
C50H71N7O14
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Aminoxyrone biochemical
Aminoxyrone is a novel peptidometic C-terminal HSP90 inhibitor by targeting HSP90 dimerization via the C-terminal domain (CTD) with Kd of 27.4uM; destabilizes BCR-ABL1 without inducing HSR in vitro and in vivo, additionally reduces pAKT-S473, pS6 expression and expression of client proteins associated with HSP90 chaperone activity, involving t-AKT, t-STAT5a, t-CRKL, cMYC, and BCL2; triggers the degradation of HSP90 client proteins without elevating the expression of HSPs (HSP70, HSP40 & HSP27); significantly inhibits cell growth and induces apoptosis of human leukemic stem cells (LSCs) with average EC50 of 20.94uM, Aminoxyrone is effective in imatinib resistant CML and lacks heat shock response.
Product Categories/Family for Aminoxyrone biochemical
References
1. Bhatia S, et al. Blood. 2018 May 3. pii: blood-2017-10-810986.
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Product Notes
The Aminoxyrone (Catalog #AAA3606998) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Aminoxyrone, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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