8- (3- Butynylthio)guanosine- 3', 5'- cyclic monophosphate (8-Bu(3-yne)T-cGMP) Biochemical

8- (3- Butynylthio)guanosine- 3', 5'- cyclic monophosphate (8-Bu(3-yne)T-cGMP), sodium salt

Cat. Num. AAA256646

• Purity: Typical analysis is >95% (HPLC/ UV/ 275 nm). The product is not sterile and has not been tested for endotoxins.
• Synonyms: 8- (3- Butynylthio)guanosine- 3'; 5'- cyclic monophosphate (8-Bu(3-yne)T-cGMP); sodium salt; 8-Bu(3-yne)T-cGMP; 5'- cyclic monophosphate (8-Bu(3-yne)T-cGMP) biochemical

• Purity/Purification: Typical analysis is >95% (HPLC/ UV/ 275 nm). The product is not sterile and has not been tested for endotoxins.
• Form/Format: Sodium. Lyophilized or crystallized sodium salt.

• Solubility: 8-Bu(3-yne)T-cGMP is soluble in water, limits have not been determined.
• SMILES: NC(NC1=O)=NC2=C1N=C(SCCC#C)N2[C@H]3[C@H](O)[C@H](O4)[C@@H](COP4([O-])=O)O3.[Na+]
• CAS Number: 2201859-36-9
• Formula: C??H??N?O?PS·Na
• Properties: Functionalized cGMP analogue for "click chemistry" reactions.
• UV: lambda max 275 nm, epsilon 14000, pH 7
• Notes: Please keep in mind that equal amounts of the compound may look different in volume. Micromolar quantities are determined by weight. The compound can even contract to small volume droplets. Normally the product is located in the conical bottom of the tube.; Please rinse tube walls carefully and preferably use ultrasonic or vortex to achieve total and uniform mixing. When opening the tube please make sure that no substance is lost within the cap.; Please keep in mind that the in vivo properties of this compound are not sufficiently characterized up to now.
• Preparation and Storage: Store at -20 degree C; It has sufficient stability at room temperature and does not need special care during handling or shipment. Nevertheless, we recommend that the compound should be stored in the freezer, for longer storage periods preferably in freeze-dried form.

Structure

Related Product Information for 8- (3- Butynylthio)guanosine- 3', 5'- cyclic monophosphate (8-Bu(3-yne)T-cGMP) biochemical

Functionalized cGMP analogue for "click chemistry" reactions. Functionalized cGMP analogue with a terminal alkyne group which can be used for copper-catalyzed azide-alkynecycloaddition (CuAAC) "click chemistry" reactions with azide-containing molecules.

References

1. Presolski, S.I.; Hong, V.P.; Finn, M.G., Curr. Protoc. Chem. Biol., 3, 153 - 162 (2011): "Copper-Catalyzed Azide-Alkyne ClickChemistry for Bioconjugation"
2. Hong, V.P.; Presolski, S.I.; Ma, C.; Finn, M.G., Angew. Chem. Int. Ed. Engl., 48, 9879 - 9883 (2009): "Analysis andoptimization of copper-catalyzed azide-alkyne cycloaddition for bioconjugation.