BAG family molecular chaperone regulator 3 Recombinant Protein | BAG3 recombinant protein

Recombinant Mus musculus BAG family molecular chaperone regulator 3

Cat. Num. AAA9422819

• Gene Names: Bag3; Bis; mg638; AA407278
• Reactivity: Mouse
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: BAG family molecular chaperone regulator 3; Recombinant Mus musculus BAG family molecular chaperone regulator 3; Bcl-2-associated athanogene 3Bcl-2-binding protein Bis; BAG3 recombinant protein

• Host: Yeast
• Reactivity: Mouse
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Full Length, 2-577aa

• Tag Info: His-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for BAG3 recombinant protein

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.

NCBI and Uniprot Product Information

• NCBI GI #: 115270960
• NCBI GeneID: 29810
• NCBI Accession #: NP_038891.4
• NCBI GenBank Nucleotide #: NM_013863.5
• UniProt Accession #: Q9JLV1; Q9CQL3; Q9JJC7
• Molecular Weight: 63.7kD
• NCBI Official Full Name: BAG family molecular chaperone regulator 3
• NCBI Official Synonym Full Names: BCL2-associated athanogene 3
• NCBI Official Symbol: Bag3
• NCBI Official Synonym Symbols: Bis; mg638; AA407278
• NCBI Protein Information: BAG family molecular chaperone regulator 3
• UniProt Protein Name: BAG family molecular chaperone regulator 3
• Protein Family: BAG family molecular chaperone regulator
• UniProt Gene Name: Bag3
• UniProt Synonym Gene Names: Bis; BAG-3

Uniprot Description

BAG3: a co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSC70. Has anti-apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport. May be involved in neuronal differentiation and migration.

Protein type: Apoptosis; Chaperone

Chromosomal Location of Human Ortholog: 7|7 F3

Cellular Component: cytoplasm; cytosol; neuron projection; nucleus; plasma membrane; Z disc

Molecular Function: adenyl-nucleotide exchange factor activity; cadherin binding; protein binding; protein complex binding

Biological Process: induction of apoptosis via death domain receptors; positive regulation of protein export from nucleus; positive regulation of transcription factor import into nucleus; protein stabilization