Aurora kinase C (Aurkc) Recombinant Protein | Aurkc recombinant protein
Recombinant Mouse Aurora kinase C (Aurkc)
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Aurora kinase C (Aurkc); Recombinant Mouse Aurora kinase C (Aurkc); Aurkc recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
1-282, Full length protein
Sequence
MEPSTSTRKHFTINDFEIGRPLGRGKFGRVYLARLKENHFIVALKVLFKSEIEKEGLEHQLRREVEIQAHLQHRNILRLYNYFYDDTRIYLILEYAPGGELYKELQRHQKLDQQRTATIIQELSDALTYCHEKKVIHRDIKPENLLLGLNGEVKISDFGWSVHTPSLRRKTMCGTLDYLPPEMIAQKPYNEMVDLWCIGVLCYELLVGKPPFESSTSSETYRRIRQVDFKFPSSVPAGAQDLISKLLRYHPSERLSLAQVLKHPWVREHSRRVLPPCVHGAS
Sequence Length
282
Species
Mouse
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for Aurkc recombinant protein
This gene encodes a member of the Aurora subfamily of serine
threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome
spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.
threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome
spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
32,907 Da
NCBI Official Full Name
Aurora kinase C
UniProt Protein Name
Aurora kinase C
Protein Family
UniProt Gene Name
Aurkc
UniProt Synonym Gene Names
Aie1; Aik3; Airk3; Ark3; Stk13; ARK-3; Aurora-related kinase 3
Uniprot Description
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
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Product Notes
The Aurkc aurkc (Catalog #AAA1163985) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-282, Full length protein. The amino acid sequence is listed below: MEPSTSTRKH FTINDFEIGR PLGRGKFGRV YLARLKENHF IVALKVLFKS EIEKEGLEHQ LRREVEIQAH LQHRNILRLY NYFYDDTRIY LILEYAPGGE LYKELQRHQK LDQQRTATII QELSDALTYC HEKKVIHRDI KPENLLLGLN GEVKISDFGW SVHTPSLRRK TMCGTLDYLP PEMIAQKPYN EMVDLWCIGV LCYELLVGKP PFESSTSSET YRRIRQVDFK FPSSVPAGAQ DLISKLLRYH PSERLSLAQV LKHPWVREHS RRVLPPCVHG AS. It is sometimes possible for the material contained within the vial of "Aurora kinase C (Aurkc), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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