Human ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 ELISA Kit | ATP6V1G2 elisa kit

Human V-type proton ATPase subunit G 2, ATP6V1G2 ELISA Kit

Cat. Num. AAA9325328

• Gene Names: ATP6V1G2; NG38; ATP6G; VMA10; ATP6G2
• Reactivity: Human
• Synonyms: ATPase; H+ transporting; lysosomal 13kDa; V1 subunit G2; Human V-type proton ATPase subunit G 2; ATP6V1G2 ELISA Kit; Human V-type proton ATPase subunit G 2 (ATP6V1G2) ELISA kit; DADB-26I14.6; ATP6G; ATP6G2; NG38; VMA10; lysosomal (vacuolar proton pump) subunit G; lysosomal; H (+) -transporting two-sector ATPase; s; ATP6V1G2 elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 323276655
• NCBI GeneID: 534
• NCBI Accession #: NP_001191007.1
• NCBI GenBank Nucleotide #: NM_001204078.1
• UniProt Accession #: O95670; Q2L6F8; Q5HYU8; Q5RJ63; B5MEF0
• Molecular Weight: 13,604 Da
• NCBI Official Full Name: V-type proton ATPase subunit G 2 isoform c
• NCBI Official Synonym Full Names: ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
• NCBI Official Symbol: ATP6V1G2
• NCBI Official Synonym Symbols: NG38; ATP6G; VMA10; ATP6G2
• NCBI Protein Information: V-type proton ATPase subunit G 2; V-ATPase 13 kDa subunit 2; vacuolar proton pump G subunit 2; vacuolar ATP synthase subunit G 2; H(+)-transporting two-sector ATPase, subunit G2; ATPase, H+ transporting, lysosomal (vacuolar proton pump)
• UniProt Protein Name: V-type proton ATPase subunit G 2
• UniProt Gene Name: ATP6V1G2
• UniProt Synonym Gene Names: ATP6G; ATP6G2; NG38; V-ATPase subunit G 2
• UniProt Entry Name: VATG2_HUMAN

NCBI Description

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of three V1 domain G subunit proteins. This gene had previous gene symbols of ATP6G and ATP6G2. Alternatively spliced transcript variants encoding different isoforms have been described. Read-through transcription also exists between this gene and the downstream DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B (DDX39B) gene. [provided by RefSeq, Feb 2011]

Uniprot Description

ATP6V1G2: Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the V-ATPase G subunit family.

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: melanosome; vacuolar proton-transporting V-type ATPase complex; cytosol; integral to synaptic vesicle membrane

Molecular Function: hydrogen-exporting ATPase activity, phosphorylative mechanism

Biological Process: interaction with host; cellular iron ion homeostasis; metabolic process; insulin receptor signaling pathway; transferrin transport; transmembrane transport