<
Western Blot (WB)
(Western Blot analysis of Hela cells using Catenin-alpha E/N Polyclonal Antibody at dilution of 1:500.)
Adherens Junction Antibody Kit
Adherens Junction Antibody Sampler Kit
Applications
Western Blot
Synonyms
Adherens Junction; Adherens Junction Antibody Sampler Kit; Adherens Junction antibody kit
Applicable Applications for Adherens Junction antibody kit
Western Blot (WB)
Western Blot (WB)
(Western Blot analysis of Hela cells using Catenin-alpha E/N Polyclonal Antibody at dilution of 1:500.)
Western Blot (WB)
(Western Blot analysis of Hela cells using Catenin-alpha E/N Polyclonal Antibody at dilution of 1:500.)
Western Blot (WB)
(Western Blot analysis of 823 cells using Catenin-beta Polyclonal Antibody at dilution of 1:2000.)
Western Blot (WB)
(Western Blot analysis of 823 cells using Catenin-beta Polyclonal Antibody at dilution of 1:2000.)
Western Blot (WB)
(Western Blot analysis of HuvEc cells with p120 Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of HuvEc cells with p120 Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of 3T3 cells using Catenin-gamma Polyclonal Antibody at dilution of 1:2000.)
Western Blot (WB)
(Western Blot analysis of 3T3 cells using Catenin-gamma Polyclonal Antibody at dilution of 1:2000.)
Related Product Information for Adherens Junction antibody kit
Background: Adherens junctions are dynamic structures that form cell-cell contacts and are important in development, differentiation, tissue integrity, morphology and cell polarity. They are composed of the transmembrane proteins, cadherins, which bind cadherins on adjacent cells in a calcium- dependent manner. On the cytoplasmic side of adherens junctions, the classic model states that cadherins are linked to the cytoskeleton through beta- and alpha-catenin. Research studies have demonstrated that loss of E- cadherin and alpha-E-catenin occurs during the progression of several human cancers, indicating that the breakdown of adherens junctions is important in cancer progression.Research studies also suggest that, rather than acting as a static link between cadherins and actin, alpha-catenin regulates actin dynamics directly, possibly by competing with the actin nucleating arp2/3 complex. alpha-catenin also plays a role in regulating beta-catenin-dependent transcriptional activity, affecting differentiation and response to Wnt signaling. alpha-catenin binds to beta-catenin in the nucleus, preventing it from regulating transcription, and levels of both proteins appear to be regulated via proteasome-dependent degradation.
Similar Products
Product Notes
The Adherens Junction (Catalog #AAA2550136) is an Antibody Kit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Adherens Junction can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the Adherens Junction for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Adherens Junction, Antibody Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
