Mouse A disintegrin and metalloproteinase with thrombospondin motifs 13 ELISA Kit | Adamts13 elisa kit
Mouse A disintegrin and metalloproteinase with thrombospondin motifs 13 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. In certain mouse strains (C57BL/6, for example) an intracisternal A-type particle (IAP) retrotransposon sequence is located in the intron 23 that causes an alternate splicing event resulting in a shorter transcript variants encoding shorter isoforms. The encoded preproprotein undergoes proteolytic processing to generate an active enzyme that cleaves von Willebrand factor (VWF) in circulating blood. [provided by RefSeq, Jul 2016]
Uniprot Description
ADAMTS13: Cleaves the vWF multimers in plasma into smaller forms. Defects in ADAMTS13 are the cause of thrombotic thrombocytopenic purpura congenital (TTP); also known as Upshaw-Schulman syndrome (USS). A hematologic disease characterized by hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and non-focal neurologic findings, decreased renal function and fever. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Calcium-binding; EC 3.4.24.87; Extracellular matrix; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2|2 A3
Cellular Component: extracellular space
Molecular Function: endopeptidase activity; peptidase activity
Biological Process: peptide catabolic process; proteolysis
Research Articles on Adamts13
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Product Notes
The Mouse Adamts13 adamts13 (Catalog #AAA9426312) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9426312 ELISA Kit recognizes Mouse Adamts13. It is sometimes possible for the material contained within the vial of "A disintegrin and metalloproteinase with thrombospondin motifs 13, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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