Mouse Disintegrin and metalloproteinase domain-containing protein 8 ELISA Kit | Adam8 elisa kit

Mouse Disintegrin and metalloproteinase domain-containing protein 8 ELISA Kit

Cat. Num. AAA2884905

• Gene Names: Adam8; MS2; CD156; ADAM 8; CD156a; E430039A18Rik
• Reactivity: Mouse
• Synonyms: Disintegrin and metalloproteinase domain-containing protein 8; Mouse Disintegrin and metalloproteinase domain-containing protein 8 ELISA Kit; ADAM 8; Cell surface antigen MS2; Macrophage cysteine-rich glycoprotein; Adam8; Ms2; 3.4.24.-; CD156a; Adam8 elisa kit

• Reactivity: Mouse
• Sequence Length: 826

• Assay Type: Sandwich
• Detection Range: 0.078-5 ng/mL
• Sensitivity: 0.045 ng/mL
• Intra-Assay CV: <=6.9%
• Inter-Assay CV: <=8.9%
• Recovery: 84%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 6680642
• NCBI GeneID: 11501
• NCBI Accession #: NP_031429.1
• NCBI GenBank Nucleotide #: NM_007403.3
• UniProt Accession #: Q05910
• Molecular Weight: 90,046 Da
• NCBI Official Full Name: disintegrin and metalloproteinase domain-containing protein 8 isoform 1
• NCBI Official Synonym Full Names: a disintegrin and metallopeptidase domain 8
• NCBI Official Symbol: Adam8
• NCBI Official Synonym Symbols: MS2; CD156; ADAM 8; CD156a; E430039A18Rik
• NCBI Protein Information: disintegrin and metalloproteinase domain-containing protein 8
• UniProt Protein Name: Disintegrin and metalloproteinase domain-containing protein 8
• Protein Family: Disintegrin and metalloproteinase domain-containing protein
• UniProt Gene Name: Adam8
• UniProt Synonym Gene Names: Ms2; ADAM 8
• UniProt Entry Name: ADAM8_MOUSE

NCBI Description

This gene encodes a member of the Adam family of proteins that contain the disintegrin and metalloprotease domains. The encoded protein is localized to the cell surface, where it is involved in the remodeling of extracellular matrix and cell migration. Mice lacking the encoded protein display persistent inflammation upon treatment with allergens. Alternative splicing of this gene results in multiple variants. [provided by RefSeq, Mar 2015]

Uniprot Description

ADAM8: Possible involvement in extravasation of leukocytes.

Protein type: Motility/polarity/chemotaxis; EC 3.4.24.-; Protease; Membrane protein, integral

Cellular Component: cell surface; cytoplasm; dense core granule membrane; integral to membrane; integral to plasma membrane; membrane; plasma membrane; podosome; specific granule

Molecular Function: calcium ion binding; cell adhesion molecule binding; hydrolase activity; integrin binding; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein binding; zinc ion binding

Biological Process: activation of NF-kappaB transcription factor; angiogenesis; blood vessel endothelial cell migration; cell morphogenesis; cell-cell adhesion; cell-matrix adhesion; inflammatory response; leukocyte migration during inflammatory response; lymphocyte chemotaxis; negative regulation of neuron apoptosis; positive regulation of acute inflammatory response; positive regulation of bone resorption; positive regulation of cell adhesion; positive regulation of cellular extravasation; positive regulation of inflammatory response; positive regulation of membrane protein ectodomain proteolysis; positive regulation of protein kinase B signaling cascade; positive regulation of T cell differentiation in the thymus; proteolysis; regulation of cell-cell adhesion; regulation of osteoclast differentiation; tissue morphogenesis