Western Blot (WB)
(Western Blot:Sample: Recombinant ADAM8, Mouse.)
Rabbit A Disintegrin And Metalloprotease 8 Polyclonal Antibody | anti-ADAM8 antibody
Polyclonal Antibody to A Disintegrin And Metalloprotease 8 (ADAM8)
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.
Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 24 months.
Stability Test:
thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Western Blot (WB)
(Western Blot:Sample: Recombinant ADAM8, Mouse.)
Western Blot (WB)
(Western Blot:Sample: Recombinant ADAM8, Mouse.)
Western Blot (WB)
(Western Blot:Sample:Lane 1: Human Raji Cells;Lane 2: Human Raw264.7 Cells;Lane 3: Human 293T Cells;Lane 4: Mouse Pancreas Tissue.)
Western Blot (WB)
(Western Blot:Sample:Lane 1: Human Raji Cells;Lane 2: Human Raw264.7 Cells;Lane 3: Human 293T Cells;Lane 4: Mouse Pancreas Tissue.)
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded Liver tissue)
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded Liver tissue)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the Adam family of proteins that contain the disintegrin and metalloprotease domains. The encoded protein is localized to the cell surface, where it is involved in the remodeling of extracellular matrix and cell migration. Mice lacking the encoded protein display persistent inflammation upon treatment with allergens. Alternative splicing of this gene results in multiple variants. [provided by RefSeq, Mar 2015]
Uniprot Description
ADAM8: Possible involvement in extravasation of leukocytes.
Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease
Chromosomal Location of Human Ortholog: 7|7 F4
Cellular Component: alpha9-beta1 integrin-ADAM8 complex; cell surface; cytoplasm; dense core granule membrane; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; podosome; specific granule
Molecular Function: calcium ion binding; cell adhesion molecule binding; hydrolase activity; integrin binding; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein binding; zinc ion binding
Biological Process: angiogenesis; blood vessel endothelial cell migration; cell morphogenesis; cell-matrix adhesion; cellular response to hypoxia; inflammatory response; leukocyte migration involved in inflammatory response; lymphocyte chemotaxis; negative regulation of neuron apoptosis; negative regulation of thymocyte aggregation; osteoclast fusion; positive regulation of acute inflammatory response; positive regulation of bone resorption; positive regulation of cell adhesion; positive regulation of cellular extravasation; positive regulation of eosinophil migration; positive regulation of fibronectin-dependent thymocyte migration; positive regulation of inflammatory response; positive regulation of innate immune response; positive regulation of MAP kinase activity; positive regulation of membrane protein ectodomain proteolysis; positive regulation of neutrophil extravasation; positive regulation of NF-kappaB transcription factor activity; positive regulation of protein kinase B signaling; positive regulation of T cell differentiation in thymus; positive regulation of T cell migration; positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; proteolysis; regulation of cell-cell adhesion; regulation of osteoclast differentiation; tissue morphogenesis
Research Articles on ADAM8
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Product Notes
The ADAM8 adam8 (Catalog #AAA2027519) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to A Disintegrin And Metalloprotease 8 (ADAM8) reacts with Mus musculus (Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's A Disintegrin And Metalloprotease 8 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB); Immunohistochemistry (IHC); Immunocytochemistry (ICC); Immunoprecipitation (IP). Western blotting: 0.5-5ug/mL Immunohistochemistry: 5-20ug/mL Immunocytochemistry: 5-20ug/mL Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the ADAM8 adam8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "A Disintegrin And Metalloprotease 8, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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