ACYP2 recombinant protein

ACYP2 Protein, Human, Recombinant (GST Tag)

Cat. Num. AAA8120265

• Gene Names: ACYP2; ACYM; ACYP
• Purity: >94% as determined by SDS-PAGE
• Synonyms: ACYP2; ACYP2 Protein; Human; Recombinant (GST Tag); Human ACYP2/Acylphosphatase-2 Protein (GST Tag); ACYM Protein; ACYP Protein; acylphosphatase 2; muscle type; ACYP2 recombinant protein

• Host: E Coli
• Purity/Purification: >94% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile 20mM Tris, 0.15M NaCl, 2mM GSH, pH7.5. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Ser2-Tyr99

• Species: Human
• Predicted N Terminal: Met
• Tag: N-GST
• Protein Construction: A DNA sequence encoding the human ACYP2 (P14621)(Ser 2-Tyr 99) was fused with the GST tag at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for ACYP2 recombinant protein

Background: Recent genome-wide association studies have identified genetic variants in ACYP2 and WFS1 that are associated with cisplatin-induced ototoxicity. We sought to explore the role of these genetic susceptibility factors to cisplatin-induced ototoxicity in patients with testicular cancer. Telomere length, as a marker of biological aging, has been reported to influence the risk of several age-related diseases, including ischemic stroke. Recent studies have identified the genetic variant within ACYP2 and TSPYL6 associated with shorter telomere length. The research showed that that the G allele of rs11896604 and the A allele of rs12615793 within ACYP2 gene, rs12615793- smoking interaction, and rs11896604-alcohol drinking interaction were all associated with increased IS risk.

References

Degl'Innocenti,D. et al., 2004, IUBMB Life. 56 (1):29-33. Gribenko A.V., et al., 2009, Proc. Natl. Acad. Sci. USA.106:2601-2606. Yeung R.C., et al., 2006, Acta Crystallogr. F 62:80-82. Burkard T.R., et al., 2011, BMC Syst. Biol. 5:17-17.

NCBI and Uniprot Product Information

• NCBI GI #: 20149322
• NCBI GeneID: 98
• NCBI Accession #: NP_612457.1
• NCBI GenBank Nucleotide #: NM_138448.3
• UniProt Accession #: P14621
• Molecular Weight: 11,140 Da
• NCBI Official Full Name: acylphosphatase-2 isoform 3
• NCBI Official Synonym Full Names: acylphosphatase 2
• NCBI Official Symbol: ACYP2
• NCBI Official Synonym Symbols: ACYM; ACYP
• NCBI Protein Information: acylphosphatase-2
• UniProt Protein Name: Acylphosphatase-2
• Protein Family: Acylphosphatase
• UniProt Gene Name: ACYP2
• UniProt Synonym Gene Names: ACYP

NCBI Description

Acylphosphatase can hydrolyze the phosphoenzyme intermediate of different membrane pumps, particularly the Ca2+/Mg2+-ATPase from sarcoplasmic reticulum of skeletal muscle. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase on the basis of their tissue localization. This gene encodes the muscle-type isoform (MT). An increase of the MT isoform is associated with muscle differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

Uniprot Description

Its physiological role is not yet clear.