Interleukin 7 Active Protein | IL7 active protein

Interleukin 7, Recombinant, Mouse (IL-7)

Cat. Num. AAA651041

• Gene Names: IL7; IL-7
• Purity: Highly Purified
• Synonyms: Interleukin 7; Recombinant; Mouse (IL-7); IL7 active protein

• Purity/Purification: Highly Purified
• Sequence: MECHIKDKEG KAYESVLMIS IDELDKMTGT DSNCPNNEPN FFRKHVCDDT KEAAFLNRAA RKLKQFLKMN ISEEFNVHLL TVSQGTQTLV NCTSKEEKNV KEQKKNDACF LKRLLREIKT CWNKILKGSI

• Biological Activity: Murine IL-7 is fully biologically active when compared to standards. The ED50 as determined by the dose-dependent stimulation of the proliferation of murine IXN/2B cells is 0.2 ng/ml, corresponding to a specific activity of 5x10e6 units/mg.
• Reconstitution: Reconstitute with dH2O to a concentration of 0.1-1.0mg/ml.
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile dH2O and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for IL7 active protein

Interleukin-7 (IL-7) is a potent lymphoid cell growth factor which affects Pre-B, Pro-B and early T cells. It will also affect mature T cells in combination with other factors such as IL-2. Murine IL-7 is a 15.0kD protein containing 129 amino acid residues.

Product Categories/Family for IL7 active protein

Growth Factors; Cytokines; Growth Factors-Interleukin

NCBI and Uniprot Product Information

• NCBI GI #: 315467869
• NCBI GeneID: 3574
• NCBI Accession #: NP_001186816.1
• NCBI GenBank Nucleotide #: NM_001199887.1
• UniProt Accession #: P13232; Q5FBY5; Q5FBY9; A0N0L3
• Molecular Weight: 14.9kD
• NCBI Official Full Name: interleukin-7 isoform 3
• NCBI Official Synonym Full Names: interleukin 7
• NCBI Official Symbol: IL7
• NCBI Official Synonym Symbols: IL-7
• NCBI Protein Information: interleukin-7
• UniProt Protein Name: Interleukin-7
• Protein Family: Interleukin
• UniProt Gene Name: IL7
• UniProt Synonym Gene Names: IL-7
• UniProt Entry Name: IL7_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]

Uniprot Description

Function: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

Subcellular location: Secreted.

Sequence similarities: Belongs to the IL-7/IL-9 family.