IL-7 active protein

Human IL-7

Cat. Num. AAA695865

• Gene Names: IL7; IL-7
• Reactivity: Species Reactivity: Human; Cross Reactivity: Monkey, Mouse, Rat
• Purity: Above 98% as determined by SDS-PAGE Analysis.
• Synonyms: IL-7; Human IL-7; Recombinant Human IL-7; IL-7 active protein

• Host: E Coli
• Reactivity: Species Reactivity: Human; Cross Reactivity: Monkey, Mouse, Rat
• Purity/Purification: Above 98% as determined by SDS-PAGE Analysis.
• Sequence: MDCDIEGKD GKQYESVLM VSIDQLLDS MKEIGSNCL NNEFNFFKR HICDANKEG MFLFRAARK LRQFLKMNS TGDFDLHLL KVSEGTTIL LNCTGQVKG RKPAALGEA QPTKSLEEN KSLKEQKKL NDLCFLKRL LQEIKTCWN KILMGTKEH

• Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine 2E8 cells is <= 0.5 ng/ml, corresponding to a specific activity of >= 2 x 106 units/mg.
• Cell Type: B Cells, T Cells, Stem Cells
• Preparation and Storage: At -20 degree C

Testing Data

Related Product Information for IL-7 active protein

IL-7 is a hematopoietic growth factor which affects primarily early B and T cells. Produced by thymic stromal cells, spleen cells and keratinocytes, IL-7 can also co-stimulate the proliferation of mature T cells in combination with other factors such as ConA and IL-2. Human and murine IL-7 is cross-species reactive. Recombinant human IL-7 is a 17.4 kDa protein containing 153 amino acid residues.

Product Categories/Family for IL-7 active protein

Innate Immunity; Adaptive Immunity; Stem Cell Research; Cancer; Inflammation

NCBI and Uniprot Product Information

• NCBI GI #: 124354
• NCBI GeneID: 3574
• UniProt Accession #: P13232; Q5FBY5; Q5FBY9; A0N0L3
• Molecular Weight: 7,687 Da
• NCBI Official Full Name: Interleukin-7
• NCBI Official Synonym Full Names: interleukin 7
• NCBI Official Symbol: IL7
• NCBI Official Synonym Symbols: IL-7
• NCBI Protein Information: interleukin-7
• UniProt Protein Name: Interleukin-7
• UniProt Gene Name: IL7
• UniProt Synonym Gene Names: IL-7
• UniProt Entry Name: IL7_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]

Uniprot Description

IL7: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Apoptosis; Cell development/differentiation; Secreted; Cell cycle regulation; Cytokine

Chromosomal Location of Human Ortholog: 8q12-q13

Cellular Component: extracellular space; extracellular region

Molecular Function: interleukin-7 receptor binding; protein binding; growth factor activity; cytokine activity

Biological Process: positive regulation of organ growth; humoral immune response; organ morphogenesis; T cell lineage commitment; positive regulation of T cell differentiation; cell-cell signaling; regulation of gene expression; homeostasis of number of cells within a tissue; positive regulation of cell proliferation; negative regulation of catalytic activity; positive regulation of B cell proliferation; negative regulation of apoptosis; bone resorption