Interleukin-20 protein (IL20) Active Protein | IL20 active protein

Recombinant Human Interleukin-20 protein (IL20) (Active)

Cat. Num. AAA969305

• Gene Names: IL20; IL-20; IL10D; ZCYTO10
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Interleukin-20 protein (IL20); Recombinant Human Interleukin-20 protein (IL20) (Active); IL-20; IL20 active protein

• Host: E Coli
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized
• Sequence Positions: 25-176aa
• Sequence: M+LKTLNLGSC VIATNLQEIR NGFSEIRGSV QAKDGNIDIR ILRRTESLQD TKPANRCCLL RHLLRLYLDR VFKNYQTPDH YTLRKISSLA NSFLTIKKDL RLCHAHMTCH CGEEAMKKYS QILSHFEKLE PQAAVVKALG ELDILLQWME ETE
• Sequence Length: 176

• Species: Homo sapiens (Human)
• Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human IL-20Ralpha and human IL-20Rbeta co-transfected murine BaF3 pro-B cells is less than 0.5 ng/ml, corresponding to a specific activity of > 2.0 ×106 IU/mg.
• Endotoxin: Less than 1.0 EU/ug as determined by LAL method.
• Protein Note: Protein will be provided with aseptic processing and endotoxin removal.
• Preparation and Storage: Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.

SDS-PAGE

Related Product Information for IL20 active protein

Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3. {ECO:0000269|PubMed:16511554}.

Product Categories/Family for IL20 active protein

Biological Active Protein; Immunology; Interleukin

NCBI and Uniprot Product Information

• NCBI GI #: 31083166
• NCBI GeneID: 50604
• NCBI Accession #: NP_061194.2
• NCBI GenBank Nucleotide #: NM_018724.3
• UniProt Accession #: Q9NYY1; Q17RB3; Q2THG6; Q96QZ6
• Molecular Weight: 17.6 kDa
• NCBI Official Full Name: interleukin-20
• NCBI Official Synonym Full Names: interleukin 20
• NCBI Official Symbol: IL20
• NCBI Official Synonym Symbols: IL-20; IL10D; ZCYTO10
• NCBI Protein Information: interleukin-20
• UniProt Protein Name: Interleukin-20
• Protein Family: Interleukin
• UniProt Gene Name: IL20
• UniProt Synonym Gene Names: ZCYTO10; IL-20

NCBI Description

The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]

Uniprot Description

IL20: Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3. Belongs to the IL-10 family.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: extracellular region

Molecular Function: interleukin-20 receptor binding

Biological Process: positive regulation of epidermal cell differentiation; positive regulation of keratinocyte differentiation; positive regulation of tyrosine phosphorylation of STAT protein; regulation of inflammatory response