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Rabbit anti-Human Ribonuclease 7 Polyclonal Antibody | anti-RNASE7 antibody

Ribonuclease 7 Antibody

Reactivity
Human
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
Ribonuclease 7; Polyclonal Antibody; Ribonuclease 7 Antibody; EC 3.1.27.-; MGC133220; ribonuclease; RNase A family; 7; RNAS7_HUMAN; RNase 7; RNASE7; SAP 2; SAP-2; Skin derived antimicrobial protein 2; Skin-derived antimicrobial protein 2; anti-RNASE7 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Ribonuclease 7 Antibody detects endogenous levels of total Ribonuclease 7.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-RNASE7 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from Human MYOCD.
Conjugation
Unconjugated
Similarity
Belongs to the pancreatic ribonuclease family.
Tissue Specificity
Expressed in collecting ducts in kidney, and in apical uroepithelium in bladder (at protein level). Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary tract and, at a low level, in the gut. Expressed in liver, kidney, skeletal muscle and heart.
Function
Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium. Causes loss of bacterial membrane integrity. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity.
Note
Detected in urine.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-RNASE7 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
ribonuclease 7
NCBI Official Synonym Full Names
ribonuclease, RNase A family, 7
NCBI Official Symbol
RNASE7
NCBI Protein Information
ribonuclease 7; RNase 7; SAP-2; skin-derived antimicrobial protein 2
UniProt Protein Name
Ribonuclease 7
Protein Family
UniProt Gene Name
RNASE7
UniProt Synonym Gene Names
RNase 7; SAP-2
UniProt Entry Name
RNAS7_HUMAN

NCBI Description

The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein has broad-spectrum antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

Uniprot Description

RNASE7: Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium. Belongs to the pancreatic ribonuclease family.

Protein type: Secreted, signal peptide; RNA-binding; EC 3.1.27.-; Secreted; Ribonuclease

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: extracellular region

Molecular Function: endonuclease activity; lipopolysaccharide binding; nucleic acid binding; peptidoglycan binding; ribonuclease activity

Biological Process: antibacterial humoral response; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; innate immune response; membrane disruption in another organism; response to bacterium

Research Articles on RNASE7

Similar Products

Product Notes

The RNASE7 rnase7 (Catalog #AAA9629725) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Ribonuclease 7 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Ribonuclease 7 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the RNASE7 rnase7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Ribonuclease 7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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